Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.
Sign Up to like & getrecommendations! Published in 2017 at "Human molecular genetics"
DOI: 10.1093/hmg/ddw424
Abstract: Stylianos Michalakis1, Lior Shaltiel1, Vithiyanjali Sothilingam2, Susanne Koch1, Verena Schludi1, Stefanie Krause1, Christina Zeitz3,4,5, Isabelle Audo3,4,5,6,7, Marie-Elise Lancelot3,4,5, Christian Hamel8, Isabelle Meunier8, Markus N. Preising9, Christoph Friedburg9, Birgit Lorenz9, Nawal Zabouri10, Silke Haverkamp10, Marina Garcia… read more here.
Keywords: defects cav1; cav1 heterozygous; mosaic synaptopathy; synaptopathy functional ... See more keywords
Heterozygous OT-I mice reveal that antigen-specific CD8+ T cells shift from apoptotic to necrotic killers in the elderly.
Sign Up to like & getrecommendations! Published in 2023 at "Aging cell"
DOI: 10.1111/acel.13824
Abstract: Numerous alterations in CD8+ T cells contribute to impaired immune responses in elderly individuals. However, the discrimination between cell-intrinsic dysfunctions and microenvironmental changes is challenging. TCR transgenic OT-I mice are utilized to investigate CD8+ T-cell… read more here.
Keywords: heterozygous mice; cell; cd8 cells; antigen specific ... See more keywords
Behavioral Phenotypes of Foxg1 Heterozygous Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.927296
Abstract: FOXG1 syndrome (FS, aka a congenital variant of Rett syndrome) is a recently defined rare and devastating neurodevelopmental disorder characterized by various symptoms, including severe intellectual disability, autistic features, involuntary, and continuous jerky movements, feeding… read more here.
Keywords: heterozygous mice; behavioral phenotypes; human individuals; foxg1 heterozygous ... See more keywords
Enhanced Effects of Chronic Restraint-Induced Psychological Stress on Total Body Fe-Irradiation-Induced Hematopoietic Toxicity in Trp53-Heterozygous Mice
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12040565
Abstract: Humans are exposed to both psychological stress (PS) and radiation in some scenarios such as manned deep-space missions. It is of great concern to verify possible enhanced deleterious effects from such concurrent exposure. Pioneer studies… read more here.
Keywords: trp53 heterozygous; toxicity trp53; hematopoietic toxicity; radiation ... See more keywords