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   Articles with "hetrombopag" as a keyword



Efficacy and Safety of Hetrombopag Versus Thrombopoietin in Promoting Platelet Engraftment After Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective, Multicenter, Randomized Controlled Clinical Trial

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recommendations! Published in 2025 at "American Journal of Hematology"

DOI: 10.1002/ajh.27746

Abstract: Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is pivotal for hematological malignancies but faces challenges in delayed platelet engraftment, poor graft function (PGF), and bleeding risks. Hetrombopag, a thrombopoietin receptor agonist, was evaluated to enhance platelet… read more here.

Keywords: hetrombopag; platelet engraftment; hematopoietic stem; platelet ... See more keywords

Adding recombinant human thrombopoietin to cyclosporine A and hetrombopag enhances the early hematologic response in transfusion-dependent non-severe aplastic anemia: a retrospective study.

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recommendations! Published in 2025 at "Hematology"

DOI: 10.1080/16078454.2025.2556514

Abstract: ABSTRACT Objectives Transfusion-dependent non-severe aplastic anemia (TD-NSAA) is a bone marrow failure disorder with high progression risk and transfusion complications, necessitating rapidly effective therapies. Recombinant human thrombopoietin (rhTPO) stimulates megakaryocyte proliferation through a mechanism distinct… read more here.

Keywords: hetrombopag; response; transfusion dependent; rhtpo ... See more keywords

Real‐world evidence of avatrombopag for the treatment of immune thrombocytopenia intolerant or ineffective to eltrombopag/hetrombopag

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recommendations! Published in 2024 at "British Journal of Haematology"

DOI: 10.1111/bjh.19800

Abstract: Due to the limited real‐world research on the application of avatrombopag (AVA) for immune thrombocytopenia (ITP) in China, we evaluated the effectiveness and safety of AVA in clinical practice. We included 121 adult ITP patients… read more here.

Keywords: immune thrombocytopenia; real world; hetrombopag; ava ... See more keywords

Hetrombopag for the management of chemotherapy-induced thrombocytopenia in patients with advanced solid tumors: a multicenter, randomized, double-blind, placebo-controlled, phase II study

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recommendations! Published in 2024 at "Therapeutic Advances in Medical Oncology"

DOI: 10.1177/17588359241260985

Abstract: Background: Chemotherapy-induced thrombocytopenia (CIT) increases the risk of bleeding, necessitates chemotherapy dose reductions and delays, and negatively impacts prognosis. Objectives: This study aimed to evaluate the efficacy and safety of hetrombopag for the management of… read more here.

Keywords: hetrombopag; solid tumors; chemotherapy; placebo ... See more keywords

A multicenter phase II study on the efficacy and safety of hetrombopag in patients with severe aplastic anemia refractory to immunosuppressive therapy

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recommendations! Published in 2022 at "Therapeutic Advances in Hematology"

DOI: 10.1177/20406207221085197

Abstract: Background: In this single-arm phase II study (NCT03557099), we evaluated the efficacy and safety of hetrombopag, a small molecule thrombopoietin (TPO) receptor agonist, in patients with severe aplastic anemia (SAA) who were refractory to standard… read more here.

Keywords: hetrombopag; safety hetrombopag; phase study; efficacy safety ... See more keywords