Interplay between hevin, SPARC, and MDGAs: modulators of neurexin-neuroligin transsynaptic bridges.
Sign Up to like & getrecommendations! Published in 2021 at "Structure"
DOI: 10.1016/j.str.2021.01.003
Abstract: Hevin is secreted by astrocytes and its synaptogenic effects are antagonized by the related protein, SPARC. Hevin stabilizes neurexin-neuroligin transsynaptic bridges in vivo. A third protein, membrane-tethered MDGA, blocks these bridges. Here, we reveal the molecular… read more here.
Keywords: sparc; neuroligin transsynaptic; hevin; transsynaptic bridges ... See more keywords
Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1101/2022.04.12.488096
Abstract: Hevin is a secreted extracellular matrix protein that is encoded by the SPARCL1 gene. Recent studies have shown that Hevin plays an important role in regulating synaptogenesis and synaptic plasticity. Mutations in the SPARCL1 gene… read more here.
Keywords: hevin; endoplasmic reticulum; hand; autism ... See more keywords
Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.161028
Abstract: High endothelial venule protein/SPARC-like 1 (hevin/Sparcl1) is an astrocyte-secreted protein that regulates synapse formation in the brain. Here we show that astrocytic hevin signaling plays a critical role in maintaining chronic pain. Compared with WT… read more here.
Keywords: hevin; hevin sparcl1; spinal cord; pain ... See more keywords
The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020234
Abstract: Astrocytic-secreted matricellular proteins have been shown to influence various aspects of synaptic function. More recently, they have been found altered in animal models of psychiatric disorders such as drug addiction. Hevin (also known as Sparc-like… read more here.
Keywords: hevin; matricellular protein; alcohol use; use disorder ... See more keywords