Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling
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DOI: 10.1172/jci.insight.161028
Abstract: High endothelial venule protein/SPARC-like 1 (hevin/Sparcl1) is an astrocyte-secreted protein that regulates synapse formation in the brain. Here we show that astrocytic hevin signaling plays a critical role in maintaining chronic pain. Compared with WT… read more here.
Keywords: hevin; hevin sparcl1; spinal cord; pain ... See more keywords