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Hexafluoroisopropyl Carbamates as Selective MAGL and Dual MAGL/FAAH Inhibitors: Biochemical and Physicochemical Properties

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1 Published in 2022 at "Chemmedchem"

DOI: 10.1002/cmdc.202100757

Abstract: A series of hexafluoroisopropyl carbamates with indolylalkyl‐ and azaindolylalkyl‐substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). The synthesized… read more here.

Keywords: hexafluoroisopropyl carbamates; carbamates selective; magl dual; selective magl ... See more keywords