Asymmetric synthesis of chiral 1,2-oxazinane and hexahydropyridazin spirocyclic scaffolds by organocatalytic [4 + 2] cycloaddition
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DOI: 10.1039/d2ra02759c
Abstract: A novel approach to synthesize chiral 1,2-oxazinane spirocyclic scaffolds by organocatalytic [4 + 2] cycloaddition reaction between methyleneindolinones and γ-aminooxy-α,β-unsaturated ester has been disclosed. Furthermore, a hydrazide 1,4-synthon is designed and synthesized to construct chiral… read more here.
Keywords: spirocyclic scaffolds; scaffolds organocatalytic; hexahydropyridazin spirocyclic; chiral oxazinane ... See more keywords