Total Synthesis of Melicoptelines C-E: Antiviral Cyclopeptides Containing a Hexahydropyrrolo[2,3-b]indole Moiety.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02339
Abstract: Melicoptelines, natural cyclopeptides containing a 3a-hydroxy hexahydropyrrolo[2,3-b]indole (HPI) moiety, exhibit anti-influenza activity. Herein, we report the first total synthesis of melicoptelines C-E (1-3, respectively). The core 3a-hydroxy HPIs were synthesized in a diastereoselective manner from… read more here.
Keywords: hexahydropyrrolo indole; synthesis; total synthesis; moiety ... See more keywords
Hexahydropyrrolo[2,3-b]indole compounds as potential therapeutics for Alzheimer Disease.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00297
Abstract: Alzheimer's disease (AD) is the most common form of dementia among the elderly and has become a leading public health concern worldwide. It represents a huge economic and psychological burden to caregivers and families. The… read more here.
Keywords: compounds potential; alzheimer disease; potential therapeutics; indole compounds ... See more keywords