Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Signalling"
DOI: 10.1016/j.cellsig.2018.03.001
Abstract: Diphosphoinositol pentakisphosphate (IP7) is critical for the exocytotic capacity of the pancreatic β-cell, but its regulation by the primary instigator of β-cell exocytosis, glucose, is unknown. The high Km for ATP of the IP7-generating enzymes,… read more here.
Keywords: insulin; inositol hexakisphosphate; sensor pancreatic; hexakisphosphate kinase ... See more keywords
Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0188852
Abstract: Inositol pyrophosphates have been implicated in a wide range of cellular processes. Inositol hexakisphosphate kinase 1 catalyzes the pyrophosphorylation of inositol hexakisphosphate into inositol 5-diphospho-1,2,3,4,6-pentakisphosphate which is important in numerous areas of cell physiology such… read more here.
Keywords: hexakisphosphate kinase; physiology; activity; inositol hexakisphosphate ... See more keywords