Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2016772118
Abstract: Significance Antibodies are crucial for the immune response against bacteria. To drive bacterial killing, antibodies should bind to the bacterial cell and induce the complement reaction. This requires target-bound IgGs to form hexameric IgG platforms… read more here.
Keywords: hexamerization; complement activation; activation; staphylococcal protein ... See more keywords
Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation
Sign Up to like & getrecommendations! Published in 2021 at "mAbs"
DOI: 10.1080/19420862.2021.1893427
Abstract: ABSTRACT Fc galactosylation is a critical quality attribute for anti-tumor recombinant immunoglobulin G (IgG)-based monoclonal antibody (mAb) therapeutics with complement-dependent cytotoxicity (CDC) as the mechanism of action. Although the correlation between galactosylation and CDC has… read more here.
Keywords: galactosylation; hexamerization; complement activation; reaction ... See more keywords