Structure and Dynamics of DNA and RNA Double Helices Obtained from the GGGGCC and CCCCGG Hexanucleotide Repeats That Are the Hallmark of C9FTD/ALS Diseases.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.6b00348
Abstract: A (GGGGCC) hexanucleotide repeat (HR) expansion in the C9ORF72 gene, and its associated antisense (CCCCGG) expansion, are considered the major cause behind frontotemporal dementia and amyotrophic lateral sclerosis. We have performed molecular dynamics simulations to… read more here.
Keywords: double helices; rna; ccccgg; dna rna ... See more keywords
Expanding the Spectrum of Movement Disorders Associated With C9orf72 Hexanucleotide Expansions
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DOI: 10.1212/nxg.0000000000000575
Abstract: Objective Hexanucleotide repeat expansions (HREs) in C9orf72 are a major cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We aimed to determine the frequency and phenomenology of movement disorders (MD) in carriers of… read more here.
Keywords: expanding spectrum; present patients; hexanucleotide; tremor ... See more keywords
C9orf72 hexanucleotide repeat expansion found in suspected spinobulbar muscular atrophy (SBMA).
Sign Up to like & getrecommendations! Published in 2022 at "Neurologia i neurochirurgia polska"
DOI: 10.5603/pjnns.a2022.0039
Abstract: INTRODUCTION The expansion of a hexanucleotide GGGGCC repeat (G4C2) in the C9orf72 locus is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In addition, C9orf72 expansion has also been… read more here.
Keywords: hexanucleotide; atrophy sbma; repeat; muscular atrophy ... See more keywords