Rapidly progressive course of Trypanosoma cruzi infection in mice heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1) gene.
Sign Up to like & getrecommendations! Published in 2018 at "Microbes and infection"
DOI: 10.1016/j.micinf.2017.09.001
Abstract: Infection with Trypanosoma cruzi causes Chagas disease and results in myocardial inflammation and cardiomyopathy. Downregulated Hexim1 expression, as in Hexim1+/- mice, reduces cardiac inflammation and fibrosis following ischemic stress. We asked whether reduced expression of… read more here.
Keywords: hexim1 mice; hexim1; infection; inflammation ... See more keywords
Non-epigenetic induction of HEXIM1 by DNMT1 inhibitors and functional relevance
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-78058-y
Abstract: We have been studying the role of Hexamethylene bisacetamide (HMBA) Induced Protein 1 (HEXIM1) as a tumor suppressor whose expression is decreased in breast and prostate cancer. The anti-cancer actions of HEXIM1 in melanomas and… read more here.
Keywords: functional relevance; hexim1; azadc induced; expression ... See more keywords
An alpha-herpesvirus employs host HEXIM1 to promote viral transcription
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Virology"
DOI: 10.1128/jvi.01392-23
Abstract: ABSTRACT Although it is widely accepted that herpesviruses utilize host RNA polymerase II (RNAPII) to transcribe viral genes, the mechanism of utilization varies significantly among herpesviruses. With the exception of herpes simplex virus 1 (HSV-1)… read more here.
Keywords: hexim1; infection; mechanism; alpha ... See more keywords