Hexokinase 2: The preferential target of trehalose‐6‐phosphate over hexokinase 1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30317
Abstract: Cancer‐related metabolic features are in part maintained by hexokinase 2 upregulation, which leads to high levels of glucose‐6‐phosphate (G6P) and is needed to provide energy and biomass to support rapid proliferation. Using a humanized model… read more here.
Keywords: target trehalose; trehalose phosphate; hexokinase preferential; preferential target ... See more keywords
Molecular characterization of hexokinase (HK) in Haemaphysalis longicornis and evaluation of HK protein- and DNA-based vaccines against adult ticks.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7346
Abstract: BACKGROUND Haemaphysalis longicornis is an obligate hematophagous ectoparasite, which transmits various pathogens to humans, livestock, and wild animals. Hexokinase (HK) is a key regulatory enzyme of the glycolytic pathway in the organisms. However, little is… read more here.
Keywords: dna; protein dna; protein; haemaphysalis longicornis ... See more keywords
MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.069
Abstract: Hexokinase-2 (HK2), the initial as well as the rate-limiting step in glycolysis, is overexpressed in many human cancers, and correlates with poor clinical outcomes. Aerobic glycolysis is a hallmark of cancer, and drugs targeting its… read more here.
Keywords: uveal melanoma; mir 216a; hexokinase; hk2 ... See more keywords
Molecular docking and simulation studies of phytocompounds derived from Centella asiatica and Andrographis paniculata against hexokinase II as mitocan agents.
Sign Up to like & getrecommendations! Published in 2021 at "Mitochondrion"
DOI: 10.1016/j.mito.2021.09.013
Abstract: Hexokinase II (HK2), a glycolytic enzyme is commonly overexpressed in most cancer types. The overexpression of HK2 is reported to promote the survival of cancer cells by facilitating the constant ATP generation and protecting the… read more here.
Keywords: andrographis paniculata; hexokinase; centella asiatica; cancer ... See more keywords
Hexokinase 1 cellular localization regulates the metabolic fate of glucose.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2022.02.028
Abstract: The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative metabolic routes, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal mitochondrial binding… read more here.
Keywords: hk1; regulates metabolic; hexokinase cellular; localization regulates ... See more keywords
A 37-amino acid loop in the Yarrowia lipolytica hexokinase impacts its activity and affinity and modulates gene expression
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-85837-8
Abstract: The oleaginous yeast Yarrowia lipolytica is a potent cell factory as it is able to use a wide variety of carbon sources to convert waste materials into value-added products. Nonetheless, there are still gaps in… read more here.
Keywords: amino acid; lipolytica hexokinase; hexokinase; acid loop ... See more keywords
One-step detection of hexokinase activity using a personal glucose meter
Sign Up to like & getrecommendations! Published in 2018 at "Analytical Methods"
DOI: 10.1039/c8ay00498f
Abstract: Hexokinase (HK) is the first key enzyme in metabolic and glycolytic pathways. Aberrations in HK activity may result in various human diseases. In this study, we present a novel, one-step, simple, and rapid method for… read more here.
Keywords: personal glucose; activity using; hexokinase; one step ... See more keywords
Arsenic trioxide suppresses acute graft‐versus‐host disease by activating the Nrf2/HO‐1 pathway in mice
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15982
Abstract: India Project Team of the International Cancer Genome Consortium (2013) Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups. Nature Communications, 4, 2873. Jamwal, M., Aggarwal, A., Das, A.,… read more here.
Keywords: arsenic trioxide; hexokinase; hexokinase deficiency; van ... See more keywords
Dioscin Inhibited Glycolysis and Induced Cell Apoptosis in Colorectal Cancer via Promoting c-myc Ubiquitination and Subsequent Hexokinase-2 Suppression
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s224062
Abstract: Purpose Dioscin is a natural product isolated from traditional Chinese medicines and is reported to have antitumor activities against several cancers. In the present study, we aimed to investigate its potency against colorectal cancers, especially… read more here.
Keywords: hexokinase; cell; dioscin; glycolysis ... See more keywords
293-OR: Mitochondrial Hexokinase Dissociation Correlates with Obesity-Induced Inflammation and Regulates the Fate of Glucose
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db20-293-or
Abstract: It has been shown that high fat diet (HFD) induced obesity triggers local immune cell infiltration leading to pro-inflammatory cytokine production and subsequently to a state of chronic low-grade inflammation in adipose and spleen tissues.… read more here.
Keywords: ppp; dissociation; hexokinase; inflammation ... See more keywords
Structure, Expression, and Functional Analysis of the Hexokinase Gene Family in Cassava
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18051041
Abstract: Hexokinase (HXK) proteins play important roles in catalyzing hexose phosphorylation and sugar sensing and signaling. To investigate the roles of HXKs in cassava tuber root development, seven HXK genes (MeHXK1–7) were isolated and analyzed. A… read more here.
Keywords: analysis; hexokinase; tuber; family ... See more keywords