Azide‐ and Alkyne‐Bearing Metabolic Chemical Reporters of Glycosylation Show Structure‐Dependent Feedback Inhibition of the Hexosamine Biosynthetic Pathway
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DOI: 10.1002/cbic.201800280
Abstract: Metabolic chemical reporters (MCRs) of protein glycosylation are analogues of natural monosaccharides that bear reactive groups, like azides and alkynes. When they are added to living cells and organisms, these small molecules are biosynthetically transformed… read more here.
Keywords: metabolic chemical; biosynthetic pathway; hexosamine biosynthetic; chemical reporters ... See more keywords
PO-259 Inhibition of the hexosamine biosynthetic pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis
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DOI: 10.1136/esmoopen-2018-eacr25.291
Abstract: Introduction Cancer aberrant N- and O-linked protein glycosylation, frequently resulting from an augmented flux through the Hexosamine Biosynthetic Pathway (HBP), play different roles in tumour progression. Recent studies reported an association between the tumorigenic potential,… read more here.
Keywords: cancer; biosynthetic pathway; hexosamine biosynthetic; breast cancer ... See more keywords
A Genetic Model to Study Increased Hexosamine Biosynthetic Flux
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DOI: 10.1210/en.2017-00359
Abstract: Recently, we identified harvest moon (hmn), a fully penetrant and expressive recessive zebrafish mutant with hepatic steatosis. Larvae showed increased triacylglycerol in the absence of other obvious defects. When we attempted to raise these otherwise… read more here.
Keywords: hexosamine biosynthetic; genetic model; glcnac modification;
The dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology
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DOI: 10.3389/fendo.2022.984342
Abstract: The heart is a highly metabolic organ with extensive energy demands and hence relies on numerous fuel substrates including fatty acids and glucose. However, oxidative stress is a natural by-product of metabolism that, in excess,… read more here.
Keywords: cardiac physiology; role; physiology; hexosamine biosynthetic ... See more keywords