Novel disaccharide inhibitors for the bacterial galactosyltransferase LgtC: Design, synthesis via Heyns rearrangement, and biochemical evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate research"
DOI: 10.1016/j.carres.2020.108017
Abstract: Bacterial glycosyltransferases are potential targets for the development of novel antibiotics and anti-virulence agents. We report a novel inhibitor design for the retaining α-1,4-galactosyltransferase LgtC from Neisseria meningitidis. Our design is based on the installation… read more here.
Keywords: galactosyltransferase lgtc; heyns rearrangement; synthesis; lgtc ... See more keywords
Chiral Primary Amine Catalyzed Enantioselective Tandem Reactions Based on Heyns Rearrangement: Synthesis of α-Tertiary Amino Ketones.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00724
Abstract: Herein, we disclose a new catalytic asymmetric tandem reaction based on the Heyns rearrangement for the synthesis of chiral α-amino ketones with readily available substrates. The rearrangement is different from the Heyns rearrangement in that… read more here.
Keywords: based heyns; heyns rearrangement; amino ketones; chiral primary ... See more keywords