Deep profiling of the cleavage specificity and human substrates of snake venom metalloprotease HF3 by PICS using proteome derived peptide libraries and TAILS N-terminomics.
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DOI: 10.1021/acs.jproteome.9b00325
Abstract: Snakebite is a major medical concern in many parts of the world with metalloproteases playing important roles in the pathological effects of Viperidae venoms, including local tissue damage, hemorrhage and coagulopathy. Hemorrhagic Factor 3 (HF3),… read more here.
Keywords: hf3; cleavage; metalloprotease; cleavage sites ... See more keywords