The effects of high-fat diet and metformin on urinary metabolites in diabetes and pre-diabetes rat models.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2021
Abstract: High-fat diet (HFD) interferes with the dietary plan of patients with type 2 diabetes mellitus (T2DM). However, many diabetes patients consume food with higher fat content for a better taste bud experience. In this study,… read more here.
Keywords: fat diet; pre diabetes; hfd; diabetes pre ... See more keywords
Two weeks of high‐fat feeding disturb lipid and cholesterol molecular markers
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3358
Abstract: Metabolic disorders are often associated with liver steatosis and increased plasma cholesterol levels. However, the link between excessive lipid accumulation and impairments in cholesterol metabolism remains uninvestigated in the liver. Short term of high‐fat diet… read more here.
Keywords: hfd; cholesterol metabolism; cholesterol; involved cholesterol ... See more keywords
Ambient PM25 Plus High‐Fat Diet Exacerbated Kidney Injury in Mice by Activating Ferroptosis Mediated TGF‐β1/Smad2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70107
Abstract: The prevalence of chronic kidney disease (CKD) is on the rise globally, posing a significant public health concern. Numerous studies have indicated that the consumption of a high‐fat diet (HFD) can lead to renal injury,… read more here.
Keywords: pm2; mice; tgf smad2; ferroptosis ... See more keywords
Physical exercise positively modulates nonalcoholic steatohepatitis‐related hepatic endoplasmic reticulum stress
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30250
Abstract: Obesity is a predictive factor for the development of nonalcoholic steatohepatitis (NASH). Although some of the mechanisms associated with NASH development are still elusive, its pathogenesis relies on a complex broad spectrum of (interconnected) metabolic‐based… read more here.
Keywords: animals access; stress; hfd; hepatic endoplasmic ... See more keywords
Exercise ameliorates high‐fat diet‐induced impairment of differentiation of adipose‐derived stem cells into neuron‐like cells in rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26957
Abstract: Adipose‐derived stem cells (ADSCs) can differentiate into neurons under particular conditions. It remains largely unknown whether this differentiation potential is affected by physical conditions such as obesity, which modulates the functions of adipose tissue. In… read more here.
Keywords: hfd; adscs; like cells; differentiation ... See more keywords
Calorie restriction, but not Roux‐en‐Y gastric bypass surgery, increases [3H] PK11195 binding in a rat model of obesity
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22258
Abstract: Roux‐en‐Y gastric bypass surgery (RYGB) remains an effective weight‐loss method used to treat obesity. While it is successful in combating obesity, there are many lingering questions related to the changes in the brain following RYGB… read more here.
Keywords: hfd; surgery; sham; obesity ... See more keywords
The thrombin receptor PAR4 supports visceral adipose tissue inflammation
Sign Up to like & getrecommendations! Published in 2024 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-024-03097-5
Abstract: Thrombin inhibition suppresses adiposity, WAT inflammation and metabolic dysfunction in mice. Protease-activated receptor (PAR)1 does not account for thrombin-driven obesity, so we explored the culprit role of PAR4 in this context. Male WT and PAR-4-/-… read more here.
Keywords: par4; receptor; inflammation; hfd ... See more keywords
Metabolic Syndrome and Bone: Pharmacologically Induced Diabetes has Deleterious Effect on Bone in Growing Obese Rats
Sign Up to like & getrecommendations! Published in 2017 at "Calcified Tissue International"
DOI: 10.1007/s00223-017-0367-z
Abstract: Metabolic syndrome and osteoporosis share similar risk factors. Also, patients with diabetes have a higher risk of osteoporosis and fracture. Liver manifestations, such as non-alcoholic steatohepatitis (NASH), of metabolic syndrome are further aggravated in diabetics… read more here.
Keywords: hfd; pathology; bone; obese rats ... See more keywords
Bone Fragility in High Fat Diet-induced Obesity is Partially Independent of Type 2 Diabetes in Mice
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DOI: 10.1007/s00223-024-01252-x
Abstract: Obesity and type 2 diabetes (T2D) are risk factors for fragility fractures. It is unknown whether this elevated risk is due to a diet favoring obesity or the diabetes that often occurs with obesity. Therefore,… read more here.
Keywords: mice; bone; obesity; type diabetes ... See more keywords
Effects of ∆-9 tetrahydrocannabinol on the small intestine altered by high fructose diet: A Histopathological study
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DOI: 10.1007/s00418-024-02311-y
Abstract: The consumption of fructose is increasing day by day. Understanding the impact of increasing fructose consumption on the small intestine is crucial since the small intestine processes fructose into glucose. ∆9-Tetrahydrocannabinol (THC), a key cannabinoid,… read more here.
Keywords: high fructose; consumption; intestine; fructose diet ... See more keywords
The impact of magnesium biotinate and arginine silicate complexes on metabolic dysfunctions, antioxidant activity, inflammation, and neuromodulation in high-fat diet-fed rats
Sign Up to like & getrecommendations! Published in 2024 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-024-01434-9
Abstract: Biotin and arginine play crucial roles in lipid metabolism and may offer promising interventions against obesity. This study examined the combined effect of magnesium biotinate (MgB) and inositol-stabilized arginine silicate complex (ASI) on obesity-related oxidative… read more here.
Keywords: mgb; arginine silicate; hfd; magnesium biotinate ... See more keywords