HFD-fed mice appeared more severe spermatogenesis impairment by lead exposure: perspective from gut microbiota and the efficacy of probiotics.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12309
Abstract: BACKGROUND The mechanism of multifactorial spermatogenesis impairment is unclear. This study aims to investigate the reproductive toxicity of Pb in high-fat diet (HFD)-fed mice, and delineate the important role of gut microbiota. RESULTS Results showed… read more here.
Keywords: hfd fed; spermatogenesis; fed mice; gut microbiota ... See more keywords
Constant light exposure alters gut microbiota and short‐/medium‐chain fatty acids and aggravates PCOS‐like traits in HFD‐fed rats
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23380
Abstract: This study investigated the effects of constant light exposure on polycystic ovary syndrome (PCOS)‐like endocrine and metabolic changes in high‐fat diet (HFD)‐fed rats and to elucidate the related microbiotic mechanisms. read more here.
Keywords: hfd fed; constant light; pcos like; fed rats ... See more keywords
Novel 5-HT3 receptor antagonist QCM-4 attenuates depressive-like phenotype associated with obesity in high-fat-diet-fed mice
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4558-0
Abstract: RationaleDepression associated with obesity remains an interesting area to study the biological mechanisms and novel therapeutic intervention.ObjectivesThe present study investigates the effect of a novel 5-HT3 receptor antagonist 3-methoxy-N-p-tolylquinoxalin-2-carboxamide (QCM-4) on several pathogenic markers of… read more here.
Keywords: hfd fed; fed mice; mice; qcm ... See more keywords
A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2019.10.010
Abstract: Background and Aims GAS6 signaling, through the TAM receptor tyrosine kinases AXL and MERTK, participates in chronic liver pathologies. Here, we addressed GAS6/TAM involvement in Non-Alcoholic SteatoHepatitis (NASH) development. Methods GAS6/TAM signaling was analyzed in… read more here.
Keywords: gas6; gas6 tam; hfd fed; fed mice ... See more keywords
Differential effects of high‐fat diets before pregnancy and/or during pregnancy on fetal growth development
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.10.008
Abstract: Aims: The aim of the study was to investigate the effects of high‐fat diets before pregnancy and/or during pregnancy on fetal development. Main methods: Female mice were fed with standard diets (SD) or high‐fat diets… read more here.
Keywords: hfd fed; fed mice; high fat; pregnancy ... See more keywords
Combined exercise and calorie restriction therapies restore contractile and mitochondrial functions in skeletal muscle of obese-insulin resistant rats.
Sign Up to like & getrecommendations! Published in 2019 at "Nutrition"
DOI: 10.1016/j.nut.2018.11.031
Abstract: OBJECTIVES A combined exercise training and calorie-restriction program is the mainstream treatment of obesity. However, the effect of the dual-action program on mitochondrial function in skeletal muscles has not yet been clarified. The aim of… read more here.
Keywords: fed rats; calorie restriction; combined exercise; skeletal muscles ... See more keywords
Moringa peregrina leaf extracts produce anti-obesity, hypoglycemic, anti-hyperlipidemic, and hepatoprotective effects on high-fat diet fed rats
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.02.078
Abstract: This present research investigated the anti-obesity and hepatoprotective effects of ethanolic Moringa peregrina leaf (MPLE) and bark extracts (MPBE), in the rats fed with a high-fat diet (HFD). Healthy male rats (n = 48) were… read more here.
Keywords: hfd; moringa peregrina; fed rats; anti obesity ... See more keywords
Dietary calamondin supplementation slows the progression of non-alcoholic fatty liver disease in C57BL/6 mice fed a high-fat diet
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Food Sciences and Nutrition"
DOI: 10.1080/09637486.2020.1813262
Abstract: Abstract Obesity is associated with an increased risk of metabolic abnormalities. The citrus fruit calamondin contains nobiletin and hesperidin, which are involved in lipid metabolism, and vitamin C, which is an antioxidant. We investigated the… read more here.
Keywords: hfd; non alcoholic; hfd fed; fed mice ... See more keywords
Dendritic cell-intrinsic LKB1-AMPK/SIK signaling controls metabolic homeostasis by limiting the hepatic Th17 response during obesity.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.157948
Abstract: Obesity-associated metabolic inflammation drives the development of insulin resistance and type 2 diabetes, notably through modulating innate and adaptive immune cells in metabolic organs. The nutrient sensor liver kinase B1 (LKB1) has recently been shown… read more here.
Keywords: hepatic th17; hfd fed; th17; obesity ... See more keywords
Hepatic transcriptome analysis from HFD-fed mice defines a long noncoding RNA regulating cellular cholesterol levels[S]
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m086215
Abstract: To elucidate the transcriptomic changes of long noncoding RNAs (lncRNAs) in high-fat diet (HFD)-fed mice, we defined their hepatic transcriptome by RNA sequencing. Aberrant expression of 37 representative lncRNAs and 254 protein-coding RNAs was observed… read more here.
Keywords: protein coding; fed mice; hfd fed; cholesterol ... See more keywords
Preventive Effects of Ophiocordyceps s inensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Food and Nutrition Research"
DOI: 10.12691/jfnr-5-11-10
Abstract: Dyslipidemia is regarded as one of risk factors related to cardiovascular disease and hepatosteatosis widely. Due to westernized diet habits and lifestyle changes, there is a high prevalence of those lipid-dysregulated diseases, i.e. fatty liver,… read more here.
Keywords: fat diet; hfd fed; fed mice; high fat ... See more keywords