Ginsenosides Rc, as a novel SIRT6 activator, protects mice against high fat diet induced NAFLD
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Ginseng Research"
DOI: 10.1016/j.jgr.2020.07.005
Abstract: Abstract Background Hepatic lipid disorder impaired mitochondrial homeostasis and intracellular redox balance, triggering development of non-alcohol fatty liver disease (NAFLD), while effective therapeutic approach remains inadequate. Ginsenosides Rc has been reported to maintain glucose balance… read more here.
Keywords: fat diet; protects mice; hfd induced; high fat ... See more keywords
Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-020-00714-7
Abstract: Kdm2a catalyzes H3K36me2 demethylation to play an intriguing epigenetic regulatory role in cell proliferation, differentiation, and apoptosis. Herein we found that myeloid-specific knockout of Kdm2a (LysM-Cre-Kdm2af/f, Kdm2a−/−) promoted macrophage M2 program by reprograming metabolic homeostasis… read more here.
Keywords: kdm2a; hfd induced; induced obesity; pparg locus ... See more keywords
Assessment of Pharmacology, Safety, and Metabolic activity of Capsaicin Feeding in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45050-0
Abstract: Capsaicin (CAP) activates transient receptor potential vanilloid subfamily 1 (TRPV1) to counter high-fat diet (HFD)-induced obesity. Several studies suggest that CAP induces the browning of white adipocytes in vitro or inguinal white adipose tissue (iWAT)… read more here.
Keywords: capsaicin; hfd induced; safety; pharmacology ... See more keywords
Low molecular weight galactomannans-based standardized fenugreek seed extract ameliorates high-fat diet-induced obesity in mice via modulation of FASn, IL-6, leptin, and TRIP-Br2
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra05204b
Abstract: Background: Obesity is a complex, chronic metabolic disorder and its prevalence is increasing throughout most of the world. Low molecular weight galactomannans-based standardized fenugreek seed extract (LMWGAL-TF) has previously shown anti-diabetic and anti-hyperlipidemic potential. Aim:… read more here.
Keywords: seed; hfd induced; induced obesity; mice ... See more keywords
Flavonoid-amyloid fibril hybrid hydrogels for obesity control via the construction of gut microbiota.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00366j
Abstract: Innovative precise clinical approaches to protect humans from the alarming global growth of chronic disease epidemics, such as metabolic syndrome (MetS), are urgently needed. Here, we introduce protein hydrogels developed through the self-assembly of flavonoids… read more here.
Keywords: microbiota; flavonoid amyloid; gut microbiota; hfd induced ... See more keywords
Red blood cell β-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.93367
Abstract: Diet-induced obesity (DIO) represents the major cause for the current obesity epidemic, but the mechanism underlying DIO is unclear. β-Adrenergic receptors (β-ARs) play a major role in sympathetic nervous system-mediated (SNS-mediated) diet-induced energy expenditure (EE).… read more here.
Keywords: supply; hfd induced; diet induced; adrenergic receptors ... See more keywords
Naringenin promotes cell autophagy to improve high-fat-diet-induced atherosclerosis in ApoE-/- mice
Sign Up to like & getrecommendations! Published in 2021 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20209764
Abstract: Naringenin (NAR) is a major flavanone in citrus fruits that has multiple pharmacological attributes such as anticancer and antiatherogenic. This study aims to investigate the mechanism of NAR in high-fat-diet (HFD)-induced atherosclerosis (AS) in apolipoprotein… read more here.
Keywords: mice; high fat; induced atherosclerosis; fat diet ... See more keywords
mTORC2 protects the heart from high-fat diet-induced cardiomyopathy through mitochondrial fission in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.866210
Abstract: High-fat diet (HFD)-induced obesity has become the major risk factor for the development of cardiovascular diseases, but the underlying mechanisms remain poorly understood. Here, we use Drosophila as a model to study the role of… read more here.
Keywords: induced mitochondrial; hfd induced; mtorc2; mitochondrial fission ... See more keywords
Macrophage-Specific Connexin 43 Knockout Protects Mice from Obesity-Induced Inflammation and Metabolic Dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.925971
Abstract: Adipose tissue macrophages are a major immune cell type contributing to homeostatic maintenance and pathological adipose tissue remodeling. However, the mechanisms underlying macrophage recruitment and polarization in adipose tissue during obesity remain poorly understood. Previous… read more here.
Keywords: hfd induced; macrophage specific; adipose tissue; tissue ... See more keywords
Mulberry leaf polyphenols alleviated high-fat diet-induced obesity in mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.979058
Abstract: Mulberry leaf is an important medicinal food plant, which is rich in polyphenol compounds. Mulberry leaf polyphenols (MLP) possess significant lipid-lowering and antioxidant effects, and healthcare functions. In this study, the polyphenol content of mulberry… read more here.
Keywords: hfd induced; induced obese; mulberry leaf; mice ... See more keywords
Standardized Sanguisorba officinalis L. Extract Inhibits Adipogenesis and Promotes Thermogenesis via Reducing Oxidative Stress
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12040882
Abstract: Obesity produces many health problems, including systemic oxidative stress. This study comprehensively investigated the effects of Sanguisorba officinalis L. extract (SO) as an antioxidant on abnormal lipid accumulation and oxidative stress in 3T3-L1 adipocytes and… read more here.
Keywords: stress; hfd induced; sanguisorba officinalis; oxidative stress ... See more keywords