Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice.
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.31048
Abstract: Bone morphogenetic proteins BMP2 and BMP6 play key roles in systemic iron homeostasis by regulating production of the iron hormone hepcidin. HFE also regulates hepcidin through a mechanism that intersects with the BMP-SMAD1/5/8 pathway. However,… read more here.
Keywords: hfe; bmp2; mice; bmp6 ... See more keywords
Bimetallic Fe–Ir and Trimetallic Fe–Ir–Au Carbonyl Clusters Containing Hydride and/or Phosphine Ligands: Syntheses, Structures and DFT Studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cluster Science"
DOI: 10.1007/s10876-020-01839-y
Abstract: The reaction of [HFe 4 (CO) 12 (IrCOD)] 2− ( 1 ) with CO at ambient conditions afforded [HFe 4 Ir(CO) 14 ] 2− ( 2 ), that, in turn, reacted with HBF 4 ·Et… read more here.
Keywords: pph; carbonyl clusters; trimetallic carbonyl; hfe ... See more keywords
Fast estimation of Colles' fracture load of the distal section of the radius by homogenized finite element analysis based on HR-pQCT.
Sign Up to like & getrecommendations! Published in 2017 at "Bone"
DOI: 10.1016/j.bone.2017.01.003
Abstract: Fractures of the distal section of the radius (Colles' fractures) occur earlier in life than other osteoporotic fractures. Therefore, they can be interpreted as a warning signal for later, more deleterious fractures of vertebral bodies… read more here.
Keywords: finite element; radius; analysis; hfe ... See more keywords
Human factors and nuclear safety since 1970 – A critical review of the past, present and future
Sign Up to like & getrecommendations! Published in 2021 at "Safety Science"
DOI: 10.1016/j.ssci.2020.105021
Abstract: Abstract Human Factors and Ergonomics (HFE) has played an essential role in increasing the safety and performance of the nuclear energy industry. This review aims to critically examine past HFE research on nuclear safety and… read more here.
Keywords: nuclear safety; industry; safety; hfe ... See more keywords
Dimethyl sulfoxide as a function additive on halogen-free electrolyte for magnesium battery application.
Sign Up to like & getrecommendations! Published in 2023 at "RSC advances"
DOI: 10.1039/d3ra01707a
Abstract: Practical Mg batteries still face significant challenges in their development, like the lack of simple compatible electrolytes, self-discharge, the rapid passivation of the Mg anode, and the slow conversion reaction pathway. Here, we propose a… read more here.
Keywords: magnesium; halogen free; dmso; free electrolyte ... See more keywords
HFE and Non-HFE Hereditary Hemochromatosis Based on Screening of 854 Individuals: 12 Years of an Iranian Experience
Sign Up to like & getrecommendations! Published in 2024 at "Genetic Testing and Molecular Biomarkers"
DOI: 10.1089/gtmb.2023.0764
Abstract: Introduction: The genetics of hereditary hemochromatosis (HH) is understudied in Iran. Here, we report the result of genetic screening of 854 individuals, referred as “suspected cases of HH,” to a diagnostic laboratory in Iran over… read more here.
Keywords: 854 individuals; hereditary hemochromatosis; hfe non; screening 854 ... See more keywords
Could haemochromatosis (HFE) gene mutations affect response to iron chelation in myelodysplastic syndrome? – Response to Lucijanic and Kusec
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15938
Abstract: We appreciate the comments by Lucijanic and Kusec on our article “Mutational profile and haematological response to iron chelation in myelodysplastic syndromes (MDS)” (Fabiani et al, 2019). Following their suggestions, we further investigated the mechanisms… read more here.
Keywords: response; iron chelation; h63d; hfe ... See more keywords
Penetrance, cancer incidence and survival in HFE haemochromatosis—A population‐based cohort study
Sign Up to like & getrecommendations! Published in 2024 at "Liver International"
DOI: 10.1111/liv.15797
Abstract: Haemochromatosis is characterized by progressive iron overload affecting the liver and can cause cirrhosis and hepatocellular carcinoma. Most haemochromatosis patients are homozygous for p.C282Y in HFE, but only a minority of individuals with this genotype… read more here.
Keywords: cancer incidence; penetrance cancer; incidence survival; haemochromatosis ... See more keywords
OP0183 Association between hfe genotypes and clinical severity characteristics of calcium pyrophosphate crystal arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.4775
Abstract: Background Several metabolic disturbances that reduce the activity of pyrophosphatases have been associated with development of calcium pyrophosphate crystal arthritis (CPPCA), but there is scarce data on their influence on clinical manifestations, as such disease-specific… read more here.
Keywords: pyrophosphate crystal; cppca; hfe; crystal arthritis ... See more keywords
Abstract 4367181: New Diagnosis of Hemochromatosis in Patients Undergoing Genetic Evaluation of Early-onset Atrial Fibrillation
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4367181
Abstract: Background: Genetic testing is now recommended for select patients with early-onset atrial fibrillation (AF). Hemochromatosis is an autosomal recessive syndrome that occurs in patients who carry two pathogenic or likely-pathogenic (P/LP) variants in HFE. HFE… read more here.
Keywords: early onset; hemochromatosis; genetic testing; iron overload ... See more keywords
Linking genetics to MRI-DTI: HFE polymorphism delays Alzheimer's disease white matter degeneration in APOE4 carriers
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Alzheimer's Disease"
DOI: 10.1177/13872877251363211
Abstract: Background While APOE4 mutation impacts normal myelination through disruptions of iron and lipid homeostasis, the HFE (homeostatic iron regulatory gene) polymorphism directly participates in white matter (WM) myelination and neuroinflammations processes via modulating iron homeostasis.… read more here.
Keywords: alzheimer disease; genetics; polymorphism; degeneration ... See more keywords