HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones from indoles and isatins
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DOI: 10.1016/j.cclet.2020.03.025
Abstract: Abstract The first HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones (27 examples, up to 98% yield) from readily available indoles and isatin derivatives are described. This protocol shows well tolerance of… read more here.
Keywords: indolin ones; hfip promoted; indolyl indolin; catalyst free ... See more keywords
HFIP-promoted para-selective alkylation of anilines and phenols with tertiary alkyl bromides
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DOI: 10.1039/d3qo00342f
Abstract: A Hexafluoroisopropanol-promoted highly regioselective Friedel-Crafts alkylation of arenes has been developed in this study. Various arenes, including anilides, anisoles, and phenols, were compatible with the reaction, leading to the para-alkylated... read more here.
Keywords: alkylation anilines; para selective; alkylation; hfip promoted ... See more keywords