Cytotoxicity of novel fluorinated alternatives to long-chain perfluoroalkyl substances to human liver cell line and their binding capacity to human liver fatty acid binding protein
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Toxicology"
DOI: 10.1007/s00204-017-2055-1
Abstract: Although shorter chain homologues and other types of fluorinated chemicals are currently used as alternatives to long-chain perfluoroalkyl substances (PFASs), their safety information remains unclear and urgently needed. Here, the cytotoxicity of several fluorinated alternatives… read more here.
Keywords: long chain; alternatives long; hfpo; acid ... See more keywords
Degradation and mechanism of hexafluoropropylene oxide dimer acid by thermally activated persulfate in aqueous solutions.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.131720
Abstract: Hexafluoropropylene oxide dimer acid (HFPO-DA), an alternative of perfluorooctanoic acid (PFOA), has been detected frequently in environmental media worldwide. It has been reported that HFPO-DA is equal to or more toxic than PFOA, as well… read more here.
Keywords: degradation; dimer acid; hfpo; oxide dimer ... See more keywords
Profiling biotoxicities of hexafluoropropylene oxide trimer acid with human embryonic stem cell-based assays.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of environmental sciences"
DOI: 10.1016/j.jes.2021.08.012
Abstract: Hexafluoropropylene oxide trimer acid (HFPO-TA), an emerging replacement of perfluorooctanoic acid (PFOA), has recently been reported to be a potential environmental contaminant. Due to the similar structure to PFOA, HFPO-TA may cause comparable adverse effects… read more here.
Keywords: trimer acid; hfpo; hexafluoropropylene oxide; acid ... See more keywords
Evidence of Air Dispersion: HFPO-DA and PFOA in Ohio and West Virginia Surface Water and Soil near a Fluoropolymer Production Facility.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental science & technology"
DOI: 10.1021/acs.est.9b07384
Abstract: Perfluorooctanoic acid (PFOA) was used as a fluoropolymer manufacturing aid at a fluoropolymer production facility in Parkersburg, WV from 1951 to 2013. The manufacturer introduced a replacement surfactant hexafluoropropylene oxide dimer acid (HFPO-DA) that has… read more here.
Keywords: surface water; facility; hfpo; pfoa ... See more keywords
Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans
Sign Up to like & getrecommendations! Published in 2023 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfad004
Abstract: Abstract HFPO-DA (ammonium, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate) is a short-chain polyfluorinated alkyl substance (PFAS) used in the manufacture of some types of fluorinated polymers. Like many PFAS, toxicity studies with HFPO-DA indicate the liver is the primary target… read more here.
Keywords: hfpo; mode action; following oral; oral exposure ... See more keywords