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   Articles with "hfsr" as a keyword



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A phase II trial of the effect of perindopril on hand–foot skin reaction (HFSR) incidence and severity in patients receiving regorafenib for refractory mCRC

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recommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"

DOI: 10.1007/s00280-018-3738-x

Abstract: PurposeRegorafenib is an oral multi-kinase inhibitor that offers an OS benefit to patients with mCRC refractory to standard therapy (Grothey et al., in Lancet 381:303–312, 2013), but comes with potential significant toxicities including grade 3… read more here.

Keywords: foot skin; skin reaction; hfsr; severity ... See more keywords
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Sorafenib-associated hand-foot skin reaction: practical advice on diagnosis, mechanism, prevention, and management

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recommendations! Published in 2019 at "Expert Review of Clinical Pharmacology"

DOI: 10.1080/17512433.2019.1689122

Abstract: ABSTRACT Introduction: Sorafenib is a multitargeted tyrosine kinase inhibitor, which has been mainly used in the treatment of advanced hepatocellular carcinoma and renal cancer. However, hand-foot skin reaction (HFSR), as one of the most common… read more here.

Keywords: foot skin; mechanism; hfsr; sorafenib ... See more keywords
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Hand-foot skin reaction (HFSR) and outcomes in the phase 3 CORRECT trial of regorafenib for metastatic colorectal cancer (mCRC).

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recommendations! Published in 2017 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2017.35.15_suppl.3551

Abstract: 3551Background: Cutaneous toxicity is a known adverse effect of multikinase inhibitors and has been associated with clinical outcomes (Granito 2016). In the phase 3 CORRECT trial (NCT01103323), the multikinase inhibitor regorafenib significantly improved overall survival… read more here.

Keywords: hfsr; phase correct; hand foot; regorafenib ... See more keywords
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The Efficacy and Safety of the Shouzu Ning Decoction Treatment for Multi-Kinase Inhibitors-Associated Severe Hand–Foot Skin Reaction

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recommendations! Published in 2021 at "Cancer Management and Research"

DOI: 10.2147/cmar.s285002

Abstract: Background Multi-kinase inhibitors (MKIs) treatment plays an important role in cancer therapy, but still suffers from a high incidence of hand–foot skin reaction (HFSR), leading to MKIs dose modification or termination. Thus, there is a… read more here.

Keywords: hand foot; hfsr; treatment; multi ... See more keywords