HPLC with electrochemical detection for determining homogentisic acid and its application to urine from rats fed tyrosine-enriched food.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113253
Abstract: A highly sensitive method for determining urine homogentisic acid (HGA) is required to provide adequate diagnosis and therapy for alkaptonuria in early stages. In this study, we developed a highly sensitive high-performance liquid chromatography with… read more here.
Keywords: hga; hplc; homogentisic acid; hplc ecd ... See more keywords
The ChCl/HGA-based DES as a capable and new catalyst for the green synthesis of benzo[4,5]thiazolo[3,2-a]chromeno[4,3-d]pyrimidin-6-one
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-90953-w
Abstract: A novel deep eutectic solvent (ChCl/HGA-DES) was prepared by a mixture of two moles of choline chloride (ChCl) and one mole of 2,3-dihydroxybenzoic acid (hypogallic acid, HGA). The eutectic point phase diagram showed that the… read more here.
Keywords: chcl hga; benzo thiazolo; hga;
Hypoglycin A absorption in sheep without concurrent clinical or biochemical evidence of disease
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Veterinary Internal Medicine"
DOI: 10.1111/jvim.16077
Abstract: Abstract Background Hypoglycin A (HGA) intoxication after ingestion of Acer spp. tree material has never been confirmed in domesticated ruminants despite their similar grazing habitats. Objectives To investigate whether sheep have low HGA bioavailability caused… read more here.
Keywords: hga; hypoglycin absorption; nursing lambs; disease ... See more keywords
Human granulocytotropic anaplasmosis—A systematic review and analysis of the literature
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0012313
Abstract: Human granulocytotropic anaplasmosis (HGA) is a zoonotic tick-borne bacterial infection caused by Anaplasma phagocytophilum. While most cases are reported from North America, HGA has been recognized as an emerging disease in several regions of the… read more here.
Keywords: granulocytotropic anaplasmosis; human granulocytotropic; literature; hga ... See more keywords
Novel absorbance peak of gentisic acid following the oxidation reaction
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0232263
Abstract: Gentisic acid (GA), a metabolite of acetylsalicylic acid (ASA), and homogentisic acid (HGA), which is excreted at high levels in alkaptonuria, are divalent phenolic acids with very similar structures. Urine containing HGA is dark brown… read more here.
Keywords: oxidation reaction; hga; oxidation; acid ... See more keywords
Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12100920
Abstract: Changes in the phenylalanine (PHE)/tyrosine (TYR) pathway metabolites before and during homogentisic acid (HGA)-lowering by nitisinone in the Suitability of Nitisinone in Alkaptonuria (AKU) 2 (SONIA 2) study enabled the magnitude of the flux in… read more here.
Keywords: tyrosine; nitisinone treatment; nitisinone; ochronotic pathway ... See more keywords
Analysis of the Phenotype Differences in Siblings with Alkaptonuria
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12100990
Abstract: Alkaptonuria (AKU) is a rare autosomal recessive disorder caused by mutations within a gene coding for homogentisate 1,2-dioxygenase (HGD). To date, 251 different variants of this gene have been reported. The metabolic disorder in AKU… read more here.
Keywords: siblings alkaptonuria; analysis phenotype; phenotype differences; hga ... See more keywords