Combination treatment with growth hormone and zoledronic acid in a mouse model of Osteogenesis imperfecta.
Sign Up to like & getrecommendations! Published in 2022 at "Bone"
DOI: 10.1016/j.bone.2022.116378
Abstract: INTRODUCTION Osteogenesis imperfecta (OI) or brittle bone disease is a genetic disorder that results in bone fragility. Bisphosphonates such as zoledronic acid (ZA) are used clinically to increase bone mass and reduce fracture risk. Human… read more here.
Keywords: bone; combination; osteogenesis imperfecta; treatment ... See more keywords
Improvement of treatment adherence with growth hormone by easypod™ device: experience of an Italian centre
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DOI: 10.1186/s13052-018-0548-z
Abstract: BackgroundOne of the most important vulnerabilities falling the efficacy of recombinant human growth hormone (r-hGH) treatment is low adherence especially in young patients. This study was planned to describe the correlation between r-hGH treatment efficacy… read more here.
Keywords: treatment; treatment adherence; growth hormone; hgh ... See more keywords
Amino acid substitutions in human growth hormone affect secondary structure and receptor binding
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DOI: 10.1371/journal.pone.0282741
Abstract: The interaction between human Growth Hormone (hGH) and hGH Receptor (hGHR) has basic relevance to cancer and growth disorders, and hGH is the scaffold for Pegvisomant, an anti-acromegaly therapeutic. For the latter reason, hGH has… read more here.
Keywords: hgh; hghr; growth; growth hormone ... See more keywords
Autocrine Human Growth Hormone Promotes Invasive and Cancer Stem Cell-Like Behavior of Hepatocellular Carcinoma Cells by STAT3 Dependent Inhibition of CLAUDIN-1 Expression
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DOI: 10.3390/ijms18061274
Abstract: Despite progress in diagnosis and treatment of hepatocellular carcinoma (HCC), the clinical outcome is still unsatisfactory. Increased expression of human growth hormone (hGH) in HCC has been reported and is associated with poor survival outcome… read more here.
Keywords: hcc; claudin; expression; forced expression ... See more keywords
Topical Delivery of Cell-Penetrating Peptide-Modified Human Growth Hormone for Enhanced Wound Healing
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DOI: 10.3390/ph16030394
Abstract: Protein drugs have been emerging as a class of promising therapeutics. However, their topical application has been limited by their high molecular weight and poor permeability to the cell membrane. In this study, we aimed… read more here.
Keywords: hgh; cell; wound healing; tat hgh ... See more keywords
Alteration in cardiac PI3K/Akt/mTOR and ERK signaling pathways with the use of growth hormone and swimming, and the roles of miR21 and miR133
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DOI: 10.3892/br.2018.1179
Abstract: Athletes misuse recombinant human growth hormone (r-hGH) to enhance their performance. Although r-hGH is known to increase cardiac hypertrophy, the underlying molecular mechanism remains unclear. The aim of the present study was to investigate the… read more here.
Keywords: growth hormone; pi3k; expression; hgh ... See more keywords