Molecular and phenotypic characteristics influencing the degree of cytoreduction in high-grade serous ovarian carcinomas.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6085
Abstract: BACKGROUND High-grade serous ovarian carcinoma (HGSOC) is the deadliest ovarian cancer subtype, and survival relates to initial cytoreductive surgical treatment. The existing tools for surgical outcome prediction remain inadequate for anticipating the outcomes of the… read more here.
Keywords: high grade; grade serous; hgsoc; serous ovarian ... See more keywords
Integrated molecular profiling of patient-derived ovarian cancer models identifies clinically relevant signatures and tumor vulnerabilities.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of cancer"
DOI: 10.1002/ijc.33983
Abstract: High-grade serous ovarian carcinoma (HGSOC) is a highly aggressive and intractable neoplasm, mainly because of its rapid dissemination into the abdominal cavity, a process that is favored by tumor-associated peritoneal ascites. The precise molecular alterations… read more here.
Keywords: tumor; cancer; patient; molecular alterations ... See more keywords
Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23500
Abstract: High grade serous ovarian carcinoma (HGSOC) is lethal with insidious onset, rapid progression, poor prognosis, and limited treatment options. Polycomb repressor complexes (PRC) 1 and 2 are intimately involved in progression of many types of… read more here.
Keywords: high grade; grade serous; cbx2; hgsoc ... See more keywords
Differential histone deacetylase inhibitor-induced perturbations of the global proteome landscape in the setting of high-grade serous ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "Proteomics"
DOI: 10.1002/pmic.202100372
Abstract: High‐grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy in women. Its low survival rate is attributed to late detection, relapse, and drug resistance. The lack of effective second‐line therapeutics remains a significant… read more here.
Keywords: high grade; grade serous; ovarian cancer; hgsoc ... See more keywords
ALPL regulates the aggressive potential of high grade serous ovarian cancer cells via a non-canonical WNT pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.016
Abstract: The ALPL gene is linked to hypophosphatasia, a rare genetic disease. Owing to the inverse relationships between ALPL expression and both the International Federation of Gynecology and Obstetrics (FIGO) stages and histological grades assigned to… read more here.
Keywords: hgsoc; serous ovarian; alpl; wnt ... See more keywords
Circulating miRNA landscape identifies miR-1246 as promising diagnostic biomarker in high-grade serous ovarian carcinoma: A validation across two independent cohorts.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2016.12.017
Abstract: High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecologic neoplasm, with five-year survival rate below 30%. Early disease detection is of utmost importance to improve HGSOC cure rate. Sera from 168 HGSOC patients and… read more here.
Keywords: hgsoc; validation; high grade; mir 1246 ... See more keywords
Classification of high-grade serous ovarian carcinoma by epithelial-to-mesenchymal transition signature and homologous recombination repair genes
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic Oncology"
DOI: 10.1016/s0090-8258(21)00851-9
Abstract: Objectives: To investigate the molecular characteristics of high-grade serous ovarian cancer (HGSOC) through integrative analysis of whole exome sequencing (WES) and RNA sequencing (RNA-seq) data. Methods: We used blood samples and primary ovarian cancer tissues… read more here.
Keywords: hgsoc; serous ovarian; index; grade serous ... See more keywords
Validation analysis of the novel imaging-based prognostic radiomic signature in patients undergoing primary surgery for advanced high-grade serous ovarian cancer (HGSOC).
Sign Up to like & getrecommendations! Published in 2021 at "British journal of cancer"
DOI: 10.1038/s41416-021-01662-w
Abstract: BACKGROUND Predictive models based on radiomics features are novel, highly promising approaches for gynaecological oncology. Here, we wish to assess the prognostic value of the newly discovered Radiomic Prognostic Vector (RPV) in an independent cohort… read more here.
Keywords: cancer; rpv; high grade; serous ovarian ... See more keywords
Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13116-2
Abstract: The cell-of-origin of high grade serous ovarian carcinoma (HGSOC) remains controversial, with fallopian tube epithelium (FTE) and ovarian surface epithelium (OSE) both considered candidates. Here, by using genetically engineered mouse models and organoids, we assessed… read more here.
Keywords: hgsoc; carcinoma; origin high; epithelium ... See more keywords
Differential DNA methylation in high-grade serous ovarian cancer (HGSOC) is associated with tumor behavior
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-54401-w
Abstract: The epigenome offers an additional facet of cancer that can help categorize patients into those at risk of disease, recurrence, or treatment failure. We conducted a retrospective, nested, case-control study of advanced and recurrent high-grade… read more here.
Keywords: hgsoc; methylation; cancer; dna methylation ... See more keywords
Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117754119
Abstract: Significance Efforts to understand and find new treatment options for high-grade serous ovarian cancer (HGSOC) have been confounded by a paucity of immune-competent models that accurately reflect the genetics and biology of the disease. Here,… read more here.
Keywords: ovarian cancer; hgsoc; senescence; response ... See more keywords