Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25841
Abstract: A detrimental consequence of hypermethylation is hyperhomocysteinemia (HHcy), that causes oxidative stress, inflammation, and matrix degradation, which leads to multi‐pathology in different organs. Although, it is well known that hypermethylation leads to overall gene silencing… read more here.
Keywords: skeletal muscle; hhcy; muscle; hypermethylation ... See more keywords
Hyperhomocysteinemia is an independent risk factor for intracranial aneurysms: a case-control study in a Chinese Han population
Sign Up to like & getrecommendations! Published in 2019 at "Neurosurgical Review"
DOI: 10.1007/s10143-019-01138-9
Abstract: Intracranial aneurysms (IAs) are common lesions in the brain. There is a strong relation between hyperhomocysteinemia (HHcy) and cerebrovascular disease; we perform a retrospective study within the Chinese Han population to explore the association between… read more here.
Keywords: risk; hhcy; chinese han; study ... See more keywords
Association between hyperhomocysteinemia and stroke with atherosclerosis and small artery occlusion depends on homocysteine metabolism-related vitamin levels in Chinese patients with normal renal function
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-017-9978-3
Abstract: This study was conducted to investigate the role of different homocysteine metabolism-related vitamin (HMRV) levels in the correlation between hyperhomocysteinemia (HHCY) and ischemic stroke (IS) subtypes. Three hundred and forty-eight IS patients manifesting different vascular… read more here.
Keywords: homocysteine metabolism; hhcy; metabolism related; hmrv ... See more keywords
Prenatal hyperhomocysteinemia induces oxidative stress and accelerates ‘aging’ of mammalian neuromuscular synapses
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Developmental Neuroscience"
DOI: 10.1016/j.ijdevneu.2019.03.004
Abstract: Enhanced levels of homocysteine during pregnancy induce oxidative stress and contribute to many age‐related diseases. In this study, we analyzed age‐dependent synaptic modifications in developing neuromuscular synapses of rats with prenatal hyperhomocysteinemia (hHCY). One of… read more here.
Keywords: hhcy; neuromuscular synapses; oxidative stress; prenatal hyperhomocysteinemia ... See more keywords
Association between hyperhomocysteinaemia and the risk of all-cause and cause-specific mortality among adults in the USA
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Nutrition"
DOI: 10.1017/s0007114522002082
Abstract: Abstract Hyperhomocysteinaemia (HHcy) is associated with all-cause mortality in some disease states. However, the correlation between HHcy and the risk of mortality in the general population has rarely been researched. We aimed to evaluate the… read more here.
Keywords: cause; mortality; risk; hhcy ... See more keywords
Prevalence of hyperhomocysteinemia (HHcy) and its major determinants among hypertensive patients over 35 years of age
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Clinical Nutrition"
DOI: 10.1038/s41430-021-00983-6
Abstract: Hyperhomocysteinemia (HHcy) and hypertension are associated with cardiovascular events. However, effects of Hcy-lowing interventions on cardiovascular outcome were conflicting. Serum folate level was proposed to be a possible determinant of efficacy of extra folate supplementation… read more here.
Keywords: hhcy; age; hyperhomocysteinemia hhcy; hypertensive patients ... See more keywords
Hydrogen Sulfide Protects Hyperhomocysteinemia-Induced Renal Damage by Modulation of Caveolin and eNOS Interaction
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-38467-6
Abstract: The accumulation of homocysteine (Hcy) during chronic kidney failure (CKD) can exert toxic effects on the glomeruli and tubulo-interstitial region. Among the potential mechanisms, the formation of highly reactive metabolite, Hcy thiolactone, is known to… read more here.
Keywords: hhcy; caveolin; hyperhomocysteinemia; hydrogen sulfide ... See more keywords
Nonlinear association between blood lead and hyperhomocysteinemia among adults in the United States
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-74268-6
Abstract: Evidence regarding the association between blood lead levels (BLL) and hyperhomocysteinemia (HHcy) in US adults was limited. We aimed to investigate the association of BLL with the risk of HHcy, and to examine possible effect… read more here.
Keywords: hhcy; association; risk hhcy; among adults ... See more keywords
Homocysteine impedes neurite outgrowth recovery after intracerebral haemorrhage by downregulating pCAMK2A
Sign Up to like & getrecommendations! Published in 2023 at "Stroke and Vascular Neurology"
DOI: 10.1136/svn-2022-002165
Abstract: Hyperhomocysteinemia (HHcy) is independently associated with poorer long-term prognosis in patients with intracerebral haemorrhage (ICH); however, the effect and mechanisms of HHcy on ICH are still unclear. Here, we evaluated neurite outgrowth and neurological functional… read more here.
Keywords: intracerebral haemorrhage; outgrowth recovery; hhcy; recovery ich ... See more keywords
Elevated serum homocysteine levels are associated with the development of chronic venous ulcers.
Sign Up to like & getrecommendations! Published in 2022 at "Vascular medicine"
DOI: 10.1177/1358863x221080486
Abstract: INTRODUCTION Venous ulceration is a multifactorial disease, and whether hyperhomocysteinemia (HHcy) promotes deterioration from primary varicose veins to venous ulcers remains unproven. METHODS This study retrospectively analyzed clinical data from 717 patients to investigate the… read more here.
Keywords: development; venous ulcers; varicose veins; primary varicose ... See more keywords
N-homocysteinylation of β-arrestins biases GPCR signaling and promotes platelet activation.
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood.2024025593
Abstract: Hyperhomocysteinemia (HHcy) is strongly associated with cardiovascular diseases (CVDs), and HHcy has been identified as a risk factor for thrombotic diseases. Most patients with HHcy die from various complications closely related to thrombotic diseases. However,… read more here.
Keywords: hhcy; platelet activation; homocysteinylation arrestins; gpcr signaling ... See more keywords