Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202342
Abstract: Abstract Type 2 diabetes mellitus (T2D) is a major public health concern and is characterized by sustained hyperglycemia due to insulin resistance and destruction of insulin‐producing β cells. One pathological hallmark of T2D is the… read more here.
Keywords: protofibril specific; hiapp; human islet; type diabetes ... See more keywords
Evidence for different in vitro oligomerization behaviors of synthetic hIAPP obtained from different sources
Sign Up to like & getrecommendations! Published in 2020 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-020-02560-5
Abstract: Type 2 diabetes is characterized by the aggregation of human islet amyloid polypeptide (hIAPP), from monomer to amyloid deposits that are made of insoluble fibrils. Discrepancies concerning the nature of formed species or oligomerization kinetics… read more here.
Keywords: different sources; vitro oligomerization; evidence different; hiapp ... See more keywords
The flanking peptides issue from the maturation of the human islet amyloid polypeptide (hIAPP) slightly modulate hIAPP-fibril formation but not hIAPP-induced cell death.
Sign Up to like & getrecommendations! Published in 2019 at "Biochimie"
DOI: 10.1016/j.biochi.2019.12.005
Abstract: Type 2 diabetes mellitus is a disease characterized by the formation of amyloid fibrillar deposits consisting mainly in human islet amyloid polypeptide (hIAPP), a peptide co-produced and co-secreted with insulin. hIAPP and insulin are synthesized… read more here.
Keywords: flanking peptides; hiapp; formation; fibril formation ... See more keywords
The pressure and temperature perturbation approach reveals a whole variety of conformational substates of amyloidogenic hIAPP monitored by 2D NMR spectroscopy.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2019.106239
Abstract: The intrinsically disordered human islet amyloid polypeptide (hIAPP) is a 37 amino acid peptide hormone that is secreted by pancreatic beta cells along with glucagon and insulin. The glucose metabolism of humans is regulated by… read more here.
Keywords: conformational substates; spectroscopy; hiapp; self assembly ... See more keywords
Assessing the role of osmolytes on the conformational harmony of islet amyloid polypeptide.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.08.104
Abstract: Several pathological disorders have known linkages with the misfolding and abnormal oligomerization of peptides and proteins and their accumulation into numerous aggregates. One such peptide is human islet amyloid polypeptide (hIAPP) responsible for amyloid aggregation… read more here.
Keywords: aggregation; islet amyloid; hiapp; amyloid polypeptide ... See more keywords
Modulation of hIAPP Fibrillation by Rationally Designed Hexapeptides Revealed by Molecular Dynamics and Experimental Investigations.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.5c00269
Abstract: The misfolding and aggregation of 37-residue neuropancreatic hormone hIAPP (human islet amyloid polypeptide) to cytotoxic aggregates comprising oligomers, protofibrils, and mature fibrils have been linked to the pathogenesis of T2D (type 2 diabetes). Scrocchi et… read more here.
Keywords: kcal mol; hiapp; hiapp fibrillation; aggregation ... See more keywords
The Structure of Human IAPP Fibrils Reflects Membrane and pH Conditions
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c06971
Abstract: Physiologically relevant in vitro models of amyloid aggregation are essential for linking structural insights to disease pathology. In type 2 diabetes, aggregation of human islet amyloid polypeptide (hIAPP) into fibrils is a hallmark of β-cell… read more here.
Keywords: human iapp; hiapp fibrils; hiapp; structure ... See more keywords
A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b08830
Abstract: Transiently populated oligomers formed en route to amyloid fibrils may constitute the most toxic aggregates associated with many amyloid-associated diseases. Most nucleation theories used to describe amyloid aggregation predict low oligomer concentrations and do not… read more here.
Keywords: energy barrier; energy; hiapp; oligomeric intermediate ... See more keywords
Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28660-7
Abstract: Human islet amyloid polypeptide (hIAPP) self-assembles into amyloid fibrils which deposit in pancreatic islets of type 2 diabetes (T2D) patients. Here, we applied chemical kinetics to study the mechanism of amyloid assembly of wild-type hIAPP… read more here.
Keywords: small molecule; hiapp; aggregation; aggregation hiapp ... See more keywords
Binuclear ruthenium complexes inhibit the fibril formation of human islet amyloid polypeptide
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DOI: 10.1039/c6ra28107a
Abstract: The deposition of human islet amyloid polypeptide (hIAPP) is closely correlated with type II diabetes mellitus (T2DM). hIAPP misfolding, as a significant causative factor of T2DM, can lead to the failure of islet transplant. Therefore,… read more here.
Keywords: islet amyloid; islet; human islet; hiapp ... See more keywords
His18 promotes reactive oxidative stress production in copper-ion mediated human islet amyloid polypeptide aggregation
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DOI: 10.1039/c9ra09943c
Abstract: Copper ions play a critical role in human islet amyloid polypeptide (hIAPP) aggregation, which has been found in more than 90% of patients with type-2 diabetes (T2D). The role of Cu(II) in the cell cytotoxicity… read more here.
Keywords: islet amyloid; human islet; hiapp; copper ... See more keywords