Molecular Observations on the Regulation of hIAPP Aggregation Process and Enhancement of Autophagy by the Short Peptide LPFYPN and Its Modified Peptides of Coix Seed Prolamins.
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DOI: 10.1021/acs.jafc.4c12559
Abstract: Inhibiting the fibrotic aggregation of the human islet amyloid polypeptide (hIAPP) and accelerating aggregate clearance are crucial factors in type II diabetes regulation. Autophagy plays a central role in hIAPP fibrotic degradation. We investigated how… read more here.
Keywords: seed; hiapp aggregation; modified peptides; aggregation ... See more keywords
Hydrophobic/Hydrophilic Ratio of Amphiphilic Helix Mimetics Determines the Effects on Islet Amyloid Polypeptide Aggregation
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DOI: 10.1021/acs.jcim.1c01566
Abstract: Amyloid depositions of human islet amyloid polypeptides (hIAPP) are associated with type II diabetes (T2D) impacting millions of people globally. Accordingly, strategies against hIAPP aggregation are essential for the prevention and eventual treatment of the… read more here.
Keywords: aggregation; hydrophobic hydrophilic; helix mimetics; hiapp aggregation ... See more keywords
888-P: Targeting Toxic Human IAPP Aggregation in Type 2 Diabetes Development with Antimicrobial Peptides
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DOI: 10.2337/db25-888-p
Abstract: Introduction and Objective: Human islet amyloid polypeptide (hIAPP) is a pancreatic β-cell neuropeptide hormone co-secreted with insulin. However, it is also amyloidogenic. The hypersecretion of hIAPP in pre-diabetes is hypothesised to induce its aggregation, which… read more here.
Keywords: hiapp; hiapp aggregation; amp; 888 targeting ... See more keywords