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   Articles with "hibd" as a keyword



The Activation of PKM2 Induces Pyroptosis in Hippocampal Neurons via the NLRP3/Caspase‐1/GSDMD Pathway in Neonatal Rats With Hypoxic‐Ischemic Brain Injury

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recommendations! Published in 2024 at "Brain and Behavior"

DOI: 10.1002/brb3.70108

Abstract: The presence of hypoxic‐ischemic brain damage (HIBD) in neonates triggers a strong neuroinflammatory reaction. Pyroptosis, a programmed cell death mechanism associated with inflammation, plays a crucial role in HIBD. Pyruvate kinase M2 (PKM2) plays a… read more here.

Keywords: brain; ischemic brain; pkm2; pyroptosis ... See more keywords
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Iron overload facilitates neonatal hypoxic–ischemic brain damage via SLC7A11‐mediated ferroptosis

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recommendations! Published in 2023 at "Journal of Neuroscience Research"

DOI: 10.1002/jnr.25184

Abstract: Oxidative damage and cell death are involved in the pathogenesis of hypoxic–ischemic brain damage (HIBD). Ferroptosis is a newly identified mode of cell death that results from the oxidative damage induced by excessive iron. In… read more here.

Keywords: brain damage; iron; ferroptosis; hibd ... See more keywords

Long non-coding RNA MALAT1 sponges microRNA-429 to regulate apoptosis of hippocampal neurons in hypoxic-ischemic brain damage by regulating WNT1

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recommendations! Published in 2019 at "Brain Research Bulletin"

DOI: 10.1016/j.brainresbull.2019.06.004

Abstract: Hypoxic-ischemic brain damage (HIBD) is a common neurological disorder. Emerging reports reveal that long non-coding RNAs and microRNAs (miRs) are implicated in the progress of HIBD. In this study we tried to ascertain whether lncRNA… read more here.

Keywords: apoptosis; mir 429; hibd; malat1 ... See more keywords

NF-κB signaling pathway inhibition suppresses hippocampal neuronal apoptosis and cognitive impairment via RCAN1 in neonatal rats with hypoxic-ischemic brain damage

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recommendations! Published in 2019 at "Cell Cycle"

DOI: 10.1080/15384101.2019.1608128

Abstract: ABSTRACT NF-κB is a core transcription factor, the activation of which can lead to hypoxic-ischemic brain damage (HIBD), while RCAN1 plays a protective role in HIBD. However, the relationship between NF-κB and RCAN1 in HIBD… read more here.

Keywords: rcan1; hibd; neuronal apoptosis; signaling pathway ... See more keywords

FAM20C Modulates Neuronal Differentiation in Hypoxic-Ischemic Brain Damage via KAP1 Phosphorylation and LINE1 RNA m6A-Dependent H3K9me3 Regulation.

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recommendations! Published in 2025 at "Cell proliferation"

DOI: 10.1111/cpr.70073

Abstract: Neurodevelopmental impairment due to hypoxic–ischemic brain damage (HIBD) lacks effective biomarkers and therapeutic targets. Based on some cues from published papers, extracellular serine/threonine protein kinase FAM20C was speculated to play a crucial role in the… read more here.

Keywords: fam20c; line1; differentiation; hypoxic ischemic ... See more keywords

GluN2B-containing NMDA receptor attenuated neuronal apoptosis in the mouse model of HIBD through inhibiting endoplasmic reticulum stress-activated PERK/eIF2α signaling pathway

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recommendations! Published in 2024 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2024.1375843

Abstract: Introduction Neonatal hypoxic-ischemic brain damage (HIBD) refers to brain damage in newborns caused by hypoxia and reduced or even stopped cerebral blood flow during the perinatal period. Currently, there are no targeted treatments for neonatal… read more here.

Keywords: hibd; perk eif2; neuronal apoptosis; brain damage ... See more keywords