Tandem repeat variation near the HIC1 (hypermethylated in cancer 1) promoter predicts outcome of oxaliplatin‐based chemotherapy in patients with metastatic colorectal cancer
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DOI: 10.1002/cncr.30880
Abstract: The hypermethylated in cancer 1/sirtuin 1 (HIC1/SIRT1) axis plays an important role in regulating the nucleotide excision repair pathway, which is the main oxaliplatin‐induced damage‐repair system. On the basis of prior evidence that the variable… read more here.
Keywords: metastatic colorectal; hic1; tandem repeat; hypermethylated cancer ... See more keywords
Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells
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DOI: 10.1016/j.celrep.2018.01.070
Abstract: Summary Regulatory T (Treg) cells are critical in regulating the immune response. In vitro induced Treg (iTreg) cells have significant potential in clinical medicine. However, applying iTreg cells as therapeutics is complicated by the poor… read more here.
Keywords: human itreg; hic1; function; itreg ... See more keywords