FGF11 induced by hypoxia interacts with HIF‐1α and enhances its stability
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12547
Abstract: Fibroblast growth factor 11 (FGF11) is an intracellular FGF. Although induction of FGF11 by hypoxia has been observed in several cell types, the molecular function of FGF11 is not clearly understood yet. Here, we investigated… read more here.
Keywords: hif; fgf11 hypoxia; hypoxia; stability ... See more keywords
Hypoxia‐inducible factor‐2α directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycin
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12419
Abstract: Ovarian cancer stem cells (OCSCs) are sources of tumor chemoresistance and recurrence. A hypoxic microenvironment contributes to the chemoresistance of cancer stem cells (CSCs), but the underlying mechanism is not fully understood yet. Here, we… read more here.
Keywords: hif; cancer stem; resistance; expression ... See more keywords
Panax notoginseng saponins ameliorate cisplatin‐induced mitochondrial injury via the HIF‐1α/mitochondria/ROS pathway
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12760
Abstract: Cisplatin is a major antineoplastic drug that is used to treat solid tumors, but its use is restricted by its nephrotoxicity. Such cisplatin‐induced nephrotoxicity (CIN) is believed to occur primarily through mitochondrial damage and reactive… read more here.
Keywords: hif; hif mitochondria; panax notoginseng; cisplatin ... See more keywords
HIF‐1α‐induced upregulated miR‐322 forms a feedback loop by targeting Smurf2 and Smad7 to activate Smad3/β‐catenin/HIF‐1α, thereby improving myocardial ischemia‐reperfusion injury
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biology International"
DOI: 10.1002/cbin.11954
Abstract: Myocardial ischemia/reperfusion injury (MIRI) is a major cause of heart failure after myocardial infarction. It has been reported that miR‐322 is involved in MIRI progression, while the molecular mechanism of miR‐322 in regulating MIRI progression… read more here.
Keywords: smurf2 smad7; cell; hif; mir 322 ... See more keywords
Identification of HIF stabilizer Roxadustat and its possible metabolites in thoroughbred horses for doping control.
Sign Up to like & getrecommendations! Published in 2021 at "Drug testing and analysis"
DOI: 10.1002/dta.3014
Abstract: Hypoxia-inducible factor (HIF) stabilizer belongs to a novel class of pharmacologically active substances, which are capable of inducing the endogenous erythropoietic system. The transcriptional activator HIF has been shown to significantly increase blood haemoglobin, and… read more here.
Keywords: stabilizer roxadustat; phase; hif; hif stabilizer ... See more keywords
Targeted deletion of HIF-1α in myeloid cells of neonatal mice: decreased accumulation of myeloid-derived suppressor cells and altered microbiome.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250144
Abstract: The newborn's immune system is faced with the challenge of having to learn quickly to fight off infectious agents, but tolerating the colonization of the body surfaces with commensals without reacting with an excessive inflammatory… read more here.
Keywords: myeloid derived; suppressor cells; hif; myeloid ... See more keywords
Treatment with hypoxia‐mimetics protects cultured rat Schwann cells against oxidative stress‐induced cell death
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24019
Abstract: Schwann cell (SC) grafts promote axon regeneration in the injured spinal cord, but transplant efficacy is diminished by a high death rate in the first 2–3 days postimplantation. Both hypoxic preconditioning and pharmacological induction of the… read more here.
Keywords: hif; death; hypoxic; hypoxia ... See more keywords
Hypoxia‐inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine‐rich glycoprotein
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29754
Abstract: Mechanisms underlying progression of nonalcoholic fatty liver disease (NAFLD) are still incompletely characterized. Hypoxia and hypoxia‐inducible factors (HIFs) have been implicated in the pathogenesis of chronic liver diseases, but the actual role of HIF‐2α in… read more here.
Keywords: hif; nonalcoholic fatty; fatty liver; hypoxia ... See more keywords
SENP1/HIF‐1α axis works in angiogenesis of human dental pulp stem cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22436
Abstract: Dental diseases seriously affect the quality of life. Studying the mechanism of dental pulp stem cells (DPSCs) had far‐reaching significance for the therapy of dental diseases. In this paper, we studied the small ubiquitin‐like modifier‐specific… read more here.
Keywords: stem cells; hif; senp1; dental pulp ... See more keywords
miR‐4735‐3p regulates phenotypic modulation of vascular smooth muscle cells by targeting HIF‐1‐mediated autophagy in intracranial aneurysm
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29219
Abstract: Intracranial aneurysm (IA) is recognized as a lethal form of cerebrovascular disease mainly featured with a modulated phenotype of vascular smooth muscle cells (SMCs). It is generally believed that enhanced SMC proliferation and migration capabilities… read more here.
Keywords: proliferation migration; hif; mir; smc proliferation ... See more keywords
The Shc protein RAI promotes an adaptive cell survival program in hypoxic neuroblastoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26247
Abstract: Neuroblastoma (NB) is a highly malignant pediatric solid tumor where a hypoxic signature correlates with unfavorable patient outcome. The hypoxia‐inducible factor (HIF)‐1α plays an important role in NB progression, contributing to cell proliferation and invasiveness.… read more here.
Keywords: hif; cell survival; rai; physiology ... See more keywords