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   Articles with "hif agr" as a keyword



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Hypoxia-inducible factor-1α is involved in isoflurane-induced blood-brain barrier disruption in aged rats model of POCD

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recommendations! Published in 2018 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2017.09.004

Abstract: HIGHLIGHTSIsoflurane treatment resulted in the reversible hippocampus BBB disruption in aged rats of POCD.BBB disruption is likely related to activation of HIF‐1&agr;/VEGF‐MMPs pathways during isoflurane exposure.HIF‐1&agr; inhibition could mitigate isoflurane‐induced cognitive impairment in aged rats… read more here.

Keywords: isoflurane; isoflurane induced; disruption; hif agr ... See more keywords
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A tumoural angiogenic gateway blocker, Benzophenone‐1B represses the HIF‐1&agr; nuclear translocation and its target gene activation against neoplastic progression

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recommendations! Published in 2017 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2016.11.009

Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Hypoxia is an important module in all solid tumours to promote angiogenesis, invasion and metastasis. Stabilization and subsequent nuclear localization of HIF‐1&agr; subunits result in the activation of… read more here.

Keywords: hif; target; nuclear translocation; hif agr ... See more keywords
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Hypoxia‐inducing factor (HIF)‐1&agr;‐derived peptide capable of inducing cancer‐reactive cytotoxic T lymphocytes from HLA‐A24+ patients with renal cell carcinoma

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recommendations! Published in 2017 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.01.014

Abstract: &NA; Hypoxic tumor microenvironment makes cancer cells to be therapy‐resistant and hypoxia‐inducing factors (HIFs) play a central role in hypoxic adaptation. Especially, renal cell carcinoma (RCC) is often associated with von Hippel‐Lindau (VHL) gene mutations,… read more here.

Keywords: cancer; hla a24; rcc; hif agr ... See more keywords
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Knockdown of HIF‐1&agr; inhibits the proliferation and migration of outer root sheath cells exposed to hypoxia in vitro: An involvement of Shh pathway

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recommendations! Published in 2017 at "Life Sciences"

DOI: 10.1016/j.lfs.2017.10.011

Abstract: Aims: Outer root sheath (ORS) is a highly proliferative component of a hair follicle. This study is performed to investigate whether hypoxia‐induced elevation of hypoxia‐inducible factor (HIF)‐1&agr;, a transcriptional activator, contributes to the outgrowth of… read more here.

Keywords: shh pathway; proliferation; ors cells; hif agr ... See more keywords
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Centchroman regulates breast cancer angiogenesis via inhibition of HIF‐1&agr;/VEGFR2 signalling axis

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recommendations! Published in 2018 at "Life Sciences"

DOI: 10.1016/j.lfs.2017.11.045

Abstract: Aims: Angiogenesis is a recognized hallmark of cancer which promotes cancer cell progression and metastasis. Inhibition of angiogenesis to attenuate cancer growth is becoming desirable strategy for breast cancer management. The present study is aimed… read more here.

Keywords: cancer; hif agr; angiogenesis; breast cancer ... See more keywords
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Melatonin as an angiogenesis inhibitor to combat cancer: Mechanistic evidence

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recommendations! Published in 2017 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2017.09.022

Abstract: ABSTRACT Melatonin, a pineal indolamine, participates in different body functions and is shown to possess diverse biological activities such as anti‐tumor action. Angiogenesis inhibition is one of the mechanisms by which melatonin exerts its oncostatic… read more here.

Keywords: angiogenesis; angiogenesis inhibitor; cancer; hif agr ... See more keywords
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The p75 neurotrophin receptor enhances HIF‐dependent signaling in glioma

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recommendations! Published in 2018 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2018.08.002

Abstract: ABSTRACT Tumor hypoxia is associated with several features of aggressive glioma growth, including migration, invasion, and stemness. Most of the cellular adaptation to hypoxia is mediated by the hypoxia‐inducible factors HIF‐1&agr; and HIF‐2&agr;, but regulation… read more here.

Keywords: neurotrophin receptor; glioma; hif dependent; hif agr ... See more keywords
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Abstract 16.45 SKIN REJUVENATION THROUGH HIF-1&Agr; UPREGULATION – A NEW TREATMENT PARADIGM IN ANTI-AGING MEDICINE

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recommendations! Published in 2018 at "Plastic and Reconstructive Surgery - Global Open"

DOI: 10.1097/01.gox.0000544082.71233.df

Abstract: METHODS: Patients underwent primary abdominoplasty at a single center were retrospectively reviewed. Bodylift, lipoabdominoplasties, panniculectomies, secondary operations and pain management with patient controlled epidural analgesia were excluded. There were a total of 123 patients, whom… read more here.

Keywords: medicine; hif agr; hospital stay; abstract skin ... See more keywords
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Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing

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recommendations! Published in 2017 at "Plastic and Reconstructive Surgery"

DOI: 10.1097/prs.0000000000003072

Abstract: Background: A hallmark of diabetes mellitus is the breakdown of almost every reparative process in the human body, leading to critical impairments of wound healing. Stabilization and activity of the transcription factor hypoxia-inducible factor (HIF)-1&agr;… read more here.

Keywords: wound healing; deferoxamine; hydroxylase inhibitor; dimethyloxalylglycine ... See more keywords
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Hypoxia enhances the migration and invasion of human glioblastoma U87 cells through PI3K/Akt/mTOR/HIF-1&agr; pathway

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recommendations! Published in 2018 at "NeuroReport"

DOI: 10.1097/wnr.0000000000001156

Abstract: Widespread invasiveness, represented by the invasion and migration, is the most important characteristic of glioblastoma multiforme (GBM) and is the main reason for therapeutic failure and recurrence of the tumor. Hypoxia is one of the… read more here.

Keywords: hif agr; akt mtor; migration invasion; pi3k akt ... See more keywords
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Hepatic hepcidin/intestinal HIF-2&agr; axis maintains iron absorption during iron deficiency and overload

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recommendations! Published in 2019 at "Journal of Clinical Investigation"

DOI: 10.1172/jci122359

Abstract: Iron-related disorders are among the most prevalent diseases worldwide. Systemic iron homeostasis requires hepcidin, a liver-derived hormone that controls iron mobilization through its molecular target ferroportin (FPN), the only known mammalian iron exporter. This pathway… read more here.

Keywords: overload; intestinal hif; iron; hif agr ... See more keywords