Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism
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DOI: 10.1016/j.molmet.2020.101039
Abstract: Objective Recent evidence indicates that inhibition of prolyl hydroxylase domain (PHD) proteins can exert beneficial effects to improve metabolic abnormalities in mice and humans. However, the underlying mechanisms are not clearly understood. This study was… read more here.
Keywords: insulin; hif; inhibition; hif dependent ... See more keywords
The p75 neurotrophin receptor enhances HIF‐dependent signaling in glioma
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DOI: 10.1016/j.yexcr.2018.08.002
Abstract: ABSTRACT Tumor hypoxia is associated with several features of aggressive glioma growth, including migration, invasion, and stemness. Most of the cellular adaptation to hypoxia is mediated by the hypoxia‐inducible factors HIF‐1&agr; and HIF‐2&agr;, but regulation… read more here.
Keywords: neurotrophin receptor; glioma; hif dependent; hif agr ... See more keywords