Hypoxia-Activated Prodrug Enabling Synchronous Chemotherapy and HIF-1α Downregulation for Tumor Treatment.
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DOI: 10.1021/acs.bioconjchem.1c00131
Abstract: The overexpression of HIF-1α in solid tumors due to hypoxia is closely related to drug resistance and consequent treatment failure. Herein, we constructed a hypoxia-activated prodrug named as YC-Dox. This prodrug could be activated under… read more here.
Keywords: hif; tumor treatment; hif downregulation; hypoxia activated ... See more keywords