Hypoxia and hypoxia-inducible factors in neuroblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Cell and Tissue Research"
DOI: 10.1007/s00441-017-2701-1
Abstract: Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2.… read more here.
Keywords: hif; hypoxia hypoxia; hif hif; inducible factors ... See more keywords
Hydrogen-bonded supramolecular metal-imidazolate frameworks: gas sorption, magnetic and UV/Vis spectroscopic properties
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Inclusion Phenomena and Macrocyclic Chemistry"
DOI: 10.1007/s10847-019-00926-6
Abstract: By varying reaction parameters for the syntheses of the hydrogen-bonded metal-imidazolate frameworks (HIF) HIF-1 and HIF-2 (featuring 14 Zn and 14 Co atoms, respectively) to increase their yields and crystallinity, we found that HIF-1 is… read more here.
Keywords: hydrogen bonded; hif; gas sorption; hif hif ... See more keywords
Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Gene Therapy"
DOI: 10.1038/cgt.2016.68
Abstract: The fast proliferation of tumor cells develops faster than the vasculature, resulting, in most malignant tumors, in generation of hypoxic regions. Hypoxia renders solid tumors resistant to radiation and chemotherapeutics while providing opportunities for tumor-selective… read more here.
Keywords: hif; hif hif; creb; replication competent ... See more keywords
HIF-2α is indispensable for regulatory T cell function
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18731-y
Abstract: Hypoxia-inducible factor 1α (HIF-1α) and HIF-2α are master transcription factors that regulate cellular responses to hypoxia, but the exact function in regulatory T (Treg) cells is controversial. Here, we show that Treg cell development is… read more here.
Keywords: hif; treg cells; hif hif; cell ... See more keywords
HIF-2α not HIF-1α overexpression confers poor prognosis in non–small cell lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "Tumor Biology"
DOI: 10.1177/1010428317709637
Abstract: HIF-α may play an important role in the process of tumorigenesis as well as tumor progression. Although a number of investigations have established the significance of HIF-1α in several human tumors, there is still little… read more here.
Keywords: hif; hif hif; hif expression; expression ... See more keywords
Expression of EPO and related factors in the liver and kidney of plain and Tibetan sheep.
Sign Up to like & getrecommendations! Published in 2023 at "Histology and histopathology"
DOI: 10.14670/hh-18-592
Abstract: Erythropoietin (EPO), hypoxia-inducible factor-1α (HIF-1α), hypoxia-inducible factor-2α (HIF-2α), and vascular endothelial growth factor (VEGF) are key factors in the regulation of hypoxia, and can transcriptionally activate multiple genes under hypoxic conditions, thereby initiating large hypoxic… read more here.
Keywords: epo hif; hif; hif hif; hif vegf ... See more keywords
A Comprehensive Description of Hypoxia-inducible Factor 2α Inhibitors as Anticancer Agents: A mini-review.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220829095334
Abstract: Targeting the tumor microenvironment is a promising strategy to prevent metastasis, overcome acquired drug resistance, and improve the therapeutic effect. Hypoxia is one of the characteristics of the tumor microenvironment, which is mainly regulated by… read more here.
Keywords: hypoxia inducible; hif; hif hif; tumor ... See more keywords
Similarity in the functions of HIF-1α and HIF-2α proteins in cervical cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.6837
Abstract: Hypoxia is a common feature of many solid tumours, including cervical cancer. Aggressive tumour progression is mostly associated with hypoxia. Furthermore, hypoxic conditions in tumours are also associated with resistance to chemotherapy and radiation, and… read more here.
Keywords: hif; cancer cell; hif hif; cervical cancer ... See more keywords