HIF Inhibitors: Status of Current Clinical Development
Sign Up to like & getrecommendations! Published in 2019 at "Current Oncology Reports"
DOI: 10.1007/s11912-019-0752-z
Abstract: Purpose of ReviewIn this review, the importance of the hypoxia inducible factor (HIF) pathway in tumorigenesis and cancer treatment outcomes will be discussed. The outcomes of phase II and III clinical trials of direct HIF… read more here.
Keywords: hif; current clinical; inhibitors status; status current ... See more keywords
Synthesis and evaluation of biarylquinoline derivatives as novel HIF-1α inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105681
Abstract: Hypoxia-inducible factor (HIF)-1α is a key transcription factor that contributes to aggressive and drug-resistant phenotypes in tumor cells under hypoxic conditions. Therefore, targeting HIF-1α represents a promising therapeutic strategy for cancer drug development. In the… read more here.
Keywords: hif inhibitors; biarylquinoline derivatives; synthesis evaluation; novel hif ... See more keywords
Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00971
Abstract: Ocular diseases featuring pathologic neovascularization are the leading cause of blindness, and anti-VEGF agents have been conventionally used to treat these diseases. Recently, regulating factors upstream of VEGF, such as HIF-1α, have emerged as a… read more here.
Keywords: ocular diseases; novel scaffold; hypoxia; factor ... See more keywords
Molecular dynamics and 3D-QSAR studies on indazole derivatives as HIF-1α inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2051745
Abstract: Abstract Hypoxia-inducible factor (HIF) is a transcriptional factor which plays a crucial role in tumour metastasis thereby responsible for development of various forms of cancers. Indazole derivatives have been reported in the literature as potent… read more here.
Keywords: qsar studies; inhibitors molecular; indazole derivatives; molecular dynamics ... See more keywords
EZH2, HIF-1, and Their Inhibitors: An Overview on Pediatric Cancers
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2018.00328
Abstract: During the past decades, several discoveries have established the role of epigenetic modifications and cellular microenvironment in tumor growth and progression. One of the main representatives concerning epigenetic modification is the polycomb group (PcG). It… read more here.
Keywords: tumor; inhibitors overview; ezh2 hif; overview pediatric ... See more keywords
Specific Inhibition of HIF Activity: Can Peptides Lead the Way?
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13030410
Abstract: Simple Summary Cancer cells in solid tumors often experience lack of oxygen (hypoxia), which they overcome with the help of hypoxia inducible transcription factors (HIFs). When HIFs are activated, they stimulate the expression of many… read more here.
Keywords: hif; hifs; hypoxia; cancer ... See more keywords
Action Sites and Clinical Application of HIF-1α Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27113426
Abstract: Hypoxia-inducible factor-1α (HIF-1α) is widely distributed in human cells, and it can form different signaling pathways with various upstream and downstream proteins, mediate hypoxia signals, regulate cells to produce a series of compensatory responses to… read more here.
Keywords: application hif; action sites; hif; hif inhibitors ... See more keywords
Hif-1α Inhibitors Could Successfully Inhibit the Progression of Differentiated Thyroid Cancer in Vitro
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13090208
Abstract: Hypoxia-inducible factor (HIF)-1α plays an important role in cancer progression. In various cancers, including thyroid cancer, overexpression of HIF-1α is related to poor prognosis or treatment response. However, few studies have investigated the role of… read more here.
Keywords: hif; thyroid cancer; idf 11774; cancer ... See more keywords