Dapagliflozin‐Loaded Exosome Mimetics Facilitate Diabetic Wound Healing by HIF‐1α‐Mediated Enhancement of Angiogenesis
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DOI: 10.1002/adhm.202202751
Abstract: Angiogenesis plays a critical role in diabetic wound healing. However, no effective strategies have been developed to target endothelial cells (ECs) to facilitate diabetic wound healing. Dapagliflozin (DA) as a sodium‐glucose linked transporter 2 (SGLT2)… read more here.
Keywords: wound healing; facilitate diabetic; diabetic wound; angiogenesis ... See more keywords
The effect of indatraline on angiogenesis suppression through HIF-1α-mediated VEGF inhibition.
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DOI: 10.1016/j.bbrc.2017.02.077
Abstract: The present research reports a novel biological activity of indatraline, a compound clinically used as an antidepressant. We previously identified indatraline as an autophagy inducer. Autophagy is an intracellular catabolic pathway for degrading or recycling… read more here.
Keywords: mediated vegf; effect indatraline; hif mediated; angiogenesis ... See more keywords
Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth
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DOI: 10.3389/fphar.2022.796763
Abstract: Background: Hypoxia-inducible factor-1α (HIF-1α) induces the expression of glycolysis-related genes, which plays a direct and key role in Warburg effect. In a recent study, honokiol (HNK) was identified as one of the potential agents that… read more here.
Keywords: mediated glycolysis; hnk; hif; glycolysis ... See more keywords