Effects of dexmedetomidine on cognitive dysfunction and neuroinflammation via the HDAC2/HIF‐1α/PFKFB3 axis in a murine model of postoperative cognitive dysfunction
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DOI: 10.1002/jbt.23044
Abstract: Inhibition of histone deacetylase (HDAC) may be a useful approach in the treatment of disorders characterized by cognitive dysfunction. Dexmedetomidine (DEX), an α2‐adrenoceptor (α2‐AR) agonist, has demonstrated neuroprotective effects. Here, we attempted to investigate the… read more here.
Keywords: cognitive dysfunction; hif pfkfb3; dysfunction; hdac2 ... See more keywords
Protective Effect of Mesenchymal Stem Cells on Isolated Islets Survival and Against Hypoxia Associated With the HIF-1α/PFKFB3 Pathway
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DOI: 10.1177/09636897211073127
Abstract: Islets have a high demand for oxygen and most of them will die of hypoxia injury before and after transplantation. Hypoxic damage is one of the key factors associated with islet graft dysfunction. Mesenchymal stem… read more here.
Keywords: hif pfkfb3; effect; mesenchymal stem; mscs ... See more keywords