HIF-1α protects against oxidative stress by directly targeting mitochondria
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101109
Abstract: The transcription factor hypoxia inducible factor-1α (HIF-1α) mediates adaptive responses to oxidative stress by nuclear translocation and regulation of gene expression. Mitochondrial changes are critical for the adaptive response to oxidative stress. However, the transcriptional… read more here.
Keywords: protects oxidative; hif; hif protects; expression ... See more keywords
HIF-1α protects osteoblasts from ROS-induced apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2022.2037581
Abstract: Abstract The regulatory mechanism of hypoxia-inducible factor-1α (HIF-1α) is complex. HIF-1α may inhibit or promote apoptosis in osteoblasts under different physiological conditions, and induce bone regeneration and repair injury in coordination with angiogenesis. The relationship… read more here.
Keywords: apoptosis; hif protects; h2o2 induced; hif ... See more keywords