Integration of hypoxic HIF-α signaling in blood cancers
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.119
Abstract: Hypoxia (low O2) is a fundamental microenvironmental determinant of bone marrow (BM) pathophysiology. Recent data from molecular and clinical studies indicate that hematopoiesis and leukemogenesis are dependent upon hypoxia-inducible factors (HIFs), a family of essential… read more here.
Keywords: hif signaling; integration hypoxic; hypoxic hif; blood ... See more keywords
Remifentanil pretreatment ameliorates H/R-induced cardiac microvascular endothelial cell dysfunction by regulating the PI3K/Akt/HIF-1α signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1969843
Abstract: Restoration of blood supply through medical or surgical intervention is a commonly adopted method for acute myocardial ischemia, but is also a trigger for cardiac ischemia/reperfusion injury. Studies have shown that remifentanil (REM) displays cardioprotective… read more here.
Keywords: hif signaling; dysfunction regulating; akt hif; pi3k akt ... See more keywords
Lithium and Copper Induce the Osteogenesis-Angiogenesis Coupling of Bone Marrow Mesenchymal Stem Cells via Crosstalk between Canonical Wnt and HIF-1α Signaling Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cells International"
DOI: 10.1155/2021/6662164
Abstract: The combination of osteogenesis and angiogenesis dual-delivery trace element-carrying bioactive scaffolds and stem cells is a promising method for bone regeneration and repair. Canonical Wnt and HIF-1α signaling pathways are vital for BMSCs' osteogenic differentiation… read more here.
Keywords: hif signaling; angiogenesis; canonical wnt; osteogenesis angiogenesis ... See more keywords
Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0282223
Abstract: The microenvironment of solid tumors is characterized by oxygen and glucose deprivation. Acss2/HIF-2 signaling coordinates essential genetic regulators including acetate-dependent acetyl CoA synthetase 2 (Acss2), Creb binding protein (Cbp), Sirtuin 1 (Sirt1), and Hypoxia Inducible… read more here.
Keywords: colon cancer; acss2 hif; hif signaling;
CHANGES IN THE EXPRESSION OF NOTCH AND HIF-1Α SIGNALING MOLECULES IN PROSTATE CANCER PROGRESSION
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Approximate Reasoning"
DOI: 10.21474/ijar01/11433
Abstract: Objective: To explore the expression and clinical significance of Notch and HIF-1α signaling molecules in the progression of prostate cancer. Method: A total of 68 cases with prostate cancer were enrolled to detecting the expression… read more here.
Keywords: hif signaling; prostate cancer; notch hif; cancer ... See more keywords
Cardiovascular Risk After SARS-CoV-2 Infection Is Mediated by IL18/IL18R1/HIF-1 Signaling Pathway Axis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.780804
Abstract: Objectives Currently, cardiovascular risk associated with COVID-19 has been brought to people’s attention, but the mechanism is not clear. The aim of this study is to elucidate the mechanisms based on multiple omics data. Methodology… read more here.
Keywords: signaling pathway; analysis; hif signaling; cov infection ... See more keywords
α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2020.00262
Abstract: The microtubule-associated protein tau is closely correlated with hypometabolism in Alzheimer’s disease (AD). α-lipoic acid (LA), which is a naturally occurring cofactor in mitochondrial, has been shown to have properties that can inhibit the tau… read more here.
Keywords: hif signaling; pathology; signaling pathway; glucose metabolism ... See more keywords