Hif-1 stabilization in zebrafish neural crest
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.357
Abstract: One of the pivotal events in neurogenesis is compartmentalization where neural tissue is divided into domains and undergoes functional differentiation. A prominent example is cerebellar development which tructural and functional compartmentalization. Although the general anatomical… read more here.
Keywords: compartmentalization; hif stabilization; zebrafish neural; neural crest ... See more keywords
The Sanger Mouse Genetics Project: Understanding Neonatal Lethality
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.359
Abstract: multiple oxygen-independent factors promoting HIF-1α stabilization. In cancer, the Warburg effect/pseudohypoxia, a state characterized for a change from aerobic to anaerobic metabolism, can promote HIF-1α stabilization through PHDs inhibition by 2oxoglutarate reduction. In neural crest… read more here.
Keywords: stabilization; genetics; hif stabilization; pdgf1a ... See more keywords
Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis
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DOI: 10.1038/s41388-019-0816-4
Abstract: The hypoxia-inducible transcription factor HIF-1 is appreciated as a promising target for cancer therapy. However, conditional deletion of HIF-1 and HIF-1 target genes in cells of the tumor microenvironment can result in accelerated tumor growth,… read more here.
Keywords: hif; intestinal tumorigenesis; hif stabilization; tumor ... See more keywords
Abstract 4808: Hypoxic HIF-1α stabilization dependent on β3-adrenoceptor localization in Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4808
Abstract: Hypoxia is a condition of oxygen deficiency which occurs in most growing solid tumors and stimulates a cascade of cell signals through a family of transcription factors named as hypoxia inducible factors (HIFs) that transactivate… read more here.
Keywords: time; expression; hif; hypoxic ... See more keywords