An efficient strategy for digging protein-protein interactions for rational drug design - A case study with HIF-1α/VHL.
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DOI: 10.1016/j.ejmech.2021.113871
Abstract: The ubiquitination of the hypoxia-inducible factor-1α (HIF-1α) is mediated by interacting with the von Hippel-Lindau protein (VHL), and is associated with cancer, chronic anemia, and ischemia. VHL, an E3 ligase, has been reported to degrade… read more here.
Keywords: hif; vhl; protein protein; hif vhl ... See more keywords