A novel AMPK activator shows therapeutic potential in hepatocellular carcinoma by suppressing HIF1α‐mediated aerobic glycolysis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13211
Abstract: Hepatocellular carcinoma (HCC) is characterized by rapid growth, early vascular invasion, and high metastasis. Currently available US Food and Drug Administration (FDA)‐approved drugs show low therapeutic efficacy, limiting HCC treatment to chemotherapy. We designed and… read more here.
Keywords: hif1; hcc; aerobic glycolysis; sct 1015 ... See more keywords
High mobility group protein B1 controls liver cancer initiation through yes‐associated protein ‐dependent aerobic glycolysis
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29663
Abstract: Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver tumor metabolic reprogramming remains elusive. Here, we provide… read more here.
Keywords: protein; glycolysis; hif1; yap ... See more keywords
Polystyrene microplastics induce apoptosis and necroptosis in swine testis cells via ROS/MAPK/HIF1α pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23611
Abstract: Microplastics (MPs) generally refer to the plastic fragments or particles smaller than 5 mm in diameter, which are closely concerned due to their widespread presence in the environment. Recent studies have shown that MPs have a… read more here.
Keywords: hif1; via ros; polystyrene microplastics; apoptosis necroptosis ... See more keywords
Hypoxia-inducible factor 1α protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-1707-9
Abstract: Diabetic peripheral neuropathy (DPN) is one of the most common diabetic complications. Mechanisms underlying nerve damage and sensory loss following metabolic dysfunction remain largely unclear. Recently, hyperglycemia-induced mitochondrial dysfunction and the generation of reactive oxygen… read more here.
Keywords: inducible factor; hif1; sensory neurons; hyperglycemia ... See more keywords
HIF1α-dependent upregulation of ATAD2 promotes proliferation and migration of stomach cancer cells in response to hypoxia.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.12.130
Abstract: Stomach cancer is a difficult-to-treat disease. Lack of detection markers and limited understanding of the disease mechanisms contribute to the aggressive nature of stomach cancer cells (SCCs). Recently, an ATPase, ATAD2 has been found to… read more here.
Keywords: hypoxia; hif1; stomach cancer; stomach ... See more keywords
Inhibition of hypoxia-inducible factor-1α alleviates acinar cell necrosis in a mouse model of acute pancreatitis.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.07.043
Abstract: Hypoxia-inducible factor-1α (Hif1α) is activated in hypoxia and is closely related to oxidative stress, immunity and cell metabolism. Recently, it is reported that Hif1α is involved in atherosclerosis, ischemia-reperfusion (I/R) injury, alcoholic liver disease and… read more here.
Keywords: acute pancreatitis; hif1; inducible factor; hypoxia inducible ... See more keywords
Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice
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DOI: 10.1016/j.isci.2021.102124
Abstract: Summary HIF1-alpha expression defines metabolic compartments in the developing heart, promoting glycolytic program in the compact myocardium and mitochondrial enrichment in the trabeculae. Nonetheless, its role in cardiogenesis is debated. To assess the importance of… read more here.
Keywords: hif1 alpha; amino acid; program; activation amino ... See more keywords
Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2017.07.001
Abstract: Summary The generation of functional arterial endothelial cells (aECs) from embryonic stem cells (ESCs) holds great promise for vascular tissue engineering. However, the mechanisms underlying their generation and the potential of aECs in revascularizing ischemic… read more here.
Keywords: arterial endothelial; functional arterial; notch1 signaling; hif1 ... See more keywords
Hypoxia promotes thyroid cancer progression through HIF1α/FGF11 feedback loop.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2022.113159
Abstract: Hypoxia is an important cause of cervical lymph nodes metastasis and recurrence of thyroid cancer, but its specific mechanism remains unclear. In the present study, we constructed a hypoxia model of thyroid cancer cells and… read more here.
Keywords: hypoxia; hif1; cancer; feedback loop ... See more keywords
Streptonigrin Inhibits SENP1 and Reduces the Protein Level of Hypoxia-Inducible Factor 1α (HIF1α) in Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00947
Abstract: Streptonigrin (CAS no. 3930-19-6) is a natural product shown to have antitumor activities in clinical trials conducted in the 1960s-1970s. However, its use in clinical studies eventually faded, and the molecular mechanisms of streptonigrin antitumor… read more here.
Keywords: level hypoxia; hif1; inducible factor; hypoxia inducible ... See more keywords
HIF1α blockade reduces kidney injury in lupus nephritis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-020-0303-8
Abstract: Nature reviews | Nephrology active and pathogenic, as determined by T cell depletion experiments. Kidneyinfiltrating T cells from these mice had gene signatures suggestive of adaptations to hypoxia mediated by the transcription factor HIF1α. Chen… read more here.
Keywords: kidney damage; nephrology; hif1 blockade; lupus nephritis ... See more keywords