Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice
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DOI: 10.1016/j.isci.2021.102124
Abstract: Summary HIF1-alpha expression defines metabolic compartments in the developing heart, promoting glycolytic program in the compact myocardium and mitochondrial enrichment in the trabeculae. Nonetheless, its role in cardiogenesis is debated. To assess the importance of… read more here.
Keywords: hif1 alpha; amino acid; program; activation amino ... See more keywords
HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells
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DOI: 10.1186/s12885-018-4577-1
Abstract: BackgroundHypoxia stimulates metastasis in cancer and is linked to poor patient prognosis. In tumours, oxygen levels vary and hypoxic regions exist within a generally well-oxygenated tumour. However, whilst the heterogeneous environment is known to contribute… read more here.
Keywords: hif1 alpha; hypoxic regions; response; cancer ... See more keywords