Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia‐inducible factors HIF1α and HIF2α
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.12693
Abstract: Chemotherapy resistance is a major contributor to poor treatment responses and tumour relapse, the development of which has been strongly linked to the action of cancer stem cells (CSCs). Mounting evidence suggests that CSCs are… read more here.
Keywords: drug resistance; resistance; hif1 hif2; cancer ... See more keywords
Roles of HIF1 and HIF2 in pulmonary hypertension: it all depends on the context
Sign Up to like & getrecommendations! Published in 2019 at "European Respiratory Journal"
DOI: 10.1183/13993003.01929-2019
Abstract: Pulmonary hypertension (PH) is a diverse collection of vascular disorders that cause remodelling of small pulmonary arteries, resulting in increases in pulmonary vascular resistance and pulmonary arterial pressure. The World Health Organization classifies these disorders… read more here.
Keywords: pulmonary hypertension; roles hif1; hypertension; hif1 hif2 ... See more keywords
HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions
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DOI: 10.7150/jca.54402
Abstract: Objective: Our previous study showed that glioma stem-like cells could be induced to undergo dedifferentiation under hypoxic conditions, but the mechanism requires further study. HIF1α and HIF2α are the main molecules involved in the response… read more here.
Keywords: hif2; hif1 hif2; sox2; dedifferentiation ... See more keywords