Lidocaine attenuates lipopolysaccharide-induced inflammatory responses and protects against endotoxemia in mice by suppressing HIF1α-induced glycolysis.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.106150
Abstract: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infections. Previous studies have indicated that lidocaine, an amide local anesthetic, has anti-inflammatory properties; however, the underlying mechanism remains unclear.… read more here.
Keywords: glycolysis; attenuates lipopolysaccharide; inflammatory; hif1 induced ... See more keywords
HIF1α-Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory Macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/9029327
Abstract: Hypoxia-inducible factor (HIF) 1α is a metabolic regulator that plays an important role in immunologic responses. Previous studies have demonstrated that HIF1α participates in the M1 polarization of macrophages. To clarify the mechanism of HIF1α-induced… read more here.
Keywords: hif1 induced; hif1 overexpression; glycolysis metabolism; glycolysis ... See more keywords