Low expression of LncRNA-CAF attributed to the high expression of HIF1A in esophageal squamous cell carcinoma and gastric cancer patients.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06882-0
Abstract: PURPOSE Cancer-associated fibroblasts (CAFs) are major components of tumor microenvironment that stimulate ESCC and GC progression. The LncRNA-CAF, FLJ22447, is located in the vicinity of HIF1A, while their association remains unclear. This study aims to… read more here.
Keywords: cancer; tumor; expression; flj22447 ... See more keywords
Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108129
Abstract: Formation of the eye lens depends on the continuous differentiation of lens epithelial cells into lens fiber cells. To attain their mature structure and transparent function, nascent lens fiber cells must complete a precise cellular… read more here.
Keywords: degradation; organelles lens; non nuclear; lens fiber ... See more keywords
TNF induces glycolytic shift in fibroblast like synoviocytes via GLUT1 and HIF1A
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98651-z
Abstract: TNF is a central cytokine in the pathogenesis of rheumatoid arthritis (RA). Elevated level of TNF causes local inflammation that affects immune cells and fibroblast-like synoviocytes (FLS). Nowadays, only 20–30% of patients experience remission after… read more here.
Keywords: fibroblast like; tnf; like synoviocytes; fls ... See more keywords
Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones.
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology"
DOI: 10.1053/j.gastro.2017.01.001
Abstract: BACKGROUND & AIMS Hypoxia-inducible factor 1α subunit (HIF1A) is a transcription factor that controls the cellular response to hypoxia and is activated in hepatocytes of patients with nonalcoholic fatty liver disease (NAFLD). NAFLD increases the… read more here.
Keywords: hifko mice; control mice; cholesterol; mice ... See more keywords
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1872227
Abstract: Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem cell death, is the leading factor that undermines intrinsic repair and aggravates IDD. Previous research… read more here.
Keywords: pulposus derived; pulposus; nucleus pulposus; stem ... See more keywords
Ferroptosis‐related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17171
Abstract: Ferroptosis is a regulated cell death nexus linking metabolism, redox biology and diseases including cancer. The aim of the present study was to identify a ferroptosis‐related gene prognostic signature for stomach adenocarcinoma (STAD) by systematic… read more here.
Keywords: hif1a; stomach adenocarcinoma; ferroptosis related; ferroptosis ... See more keywords
Expression pattern of HIF1alpha and vasohibins during follicle maturation and corpus luteum function in the bovine ovary
Sign Up to like & getrecommendations! Published in 2017 at "Reproduction in Domestic Animals"
DOI: 10.1111/rda.12867
Abstract: The aim of this study was to characterize expression patterns of hypoxia-inducible factor-1alpha (HIF1A) and vasohibin family members (VASH1 and VASH2) during different stages of ovarian function in cow. Experiment 1: Antral follicle classification occurred… read more here.
Keywords: pattern; bovine ovary; expression; function ... See more keywords
PO-240 WWOX suppressor gene regulate glucose metabolism and warburg effect in case of gestational diabetes mellitusas well as breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.273
Abstract: Introduction WWOX gene is a tumour suppressor which loss of expression is demonstrated in many cancers. WWOX is involved in the regulation of glucose metabolism by interaction with HIF1α. WWOX knockdown regulates the metabolic switch… read more here.
Keywords: expression; hif1a; wwox; breast cancer ... See more keywords
Abstract 4743: Inhibition of the Hif1a-mediated checkpoint refuels NK activation in cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4743
Abstract: Solid tumors remain a major challenge for immunotherapy of cancer due to their immunosuppressive microenvironment. Hypoxia is a common feature of solid tumors and might affect immune cell activation within the tumor tissue. Upon hypoxia… read more here.
Keywords: activation cancer; cancer; cell; hif1a ... See more keywords
Abstract 3736: ZBTB46/FOXA2/HIF1A transcription activator complex promotes MCTP1-regulated neuroendocrine differentiation and epithelial-to-mesenchymal transition
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3736
Abstract: Androgen deprivation therapy (ADT)-induced neuroendocrine differentiation (NED) is a well-known lethal subtype of prostate cancer (PCa) with a median survival rate of less than one year. Despite the increasing research attention on this variant of… read more here.
Keywords: hif1a; pca; foxa2 hif1a; zbtb46 foxa2 ... See more keywords
Down regulation of RNA binding motif, single-stranded interacting protein 3, along with up regulation of nuclear HIF1A correlates with poor prognosis in patients with gastric cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13605
Abstract: Frequent loss of multiple regions in short arm of chromosome 3 is found in various tumors including gastric cancer (GC). RNA binding motif, single-stranded interacting protein 3 (RBMS3) is a tumor suppressor gene located in… read more here.
Keywords: gastric cancer; prognosis; nuclear hif1a; hif1a ... See more keywords