Deciphering the molecular mechanism of long non-coding RNA HIF1A-AS1 regulating pancreatic cancer cells
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DOI: 10.1097/ms9.0000000000002097
Abstract: Background: HIF1A-AS1, an antisense transcript of HIF1α gene, is a 652-bp LncRNA that is globally expressed in multiple tissues of animals. Recent evidence indicated that HIF1A-AS1 was involved in tumorigenesis of several types of cancer.… read more here.
Keywords: hif1a as1; cancer; hif1a; molecular mechanism ... See more keywords
LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway
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DOI: 10.1158/0008-5472.can-21-0281
Abstract: These findings show that a reciprocal feedback of HIF1A-AS1 and HIF1α promotes gemcitabine resistance of pancreatic cancer, which provides an applicable therapeutic target. Gemcitabine (GEM) resistance is a major challenge for chemotherapy of pancreatic cancer.… read more here.
Keywords: hif1; cancer; hif1a as1; resistance pancreatic ... See more keywords
Inhibition of HIF1A-AS1 promoted starvation-induced hepatocellular carcinoma cell apoptosis by reducing HIF-1α/mTOR-mediated autophagy
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DOI: 10.1186/s12957-020-01884-x
Abstract: Background Hepatocellular carcinoma (HCC) is still a major health burden in China considering its high incidence and mortality. Long non-coding RNAs (lncRNAs) were found playing vital roles in tumor progression, suggesting a new way of… read more here.
Keywords: cell; hcc; hif1a as1; inhibition ... See more keywords