USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2α
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30686
Abstract: Hypoxia‐inducible factor 2α (HIF2α) plays a pivotal role in breast tumor growth and metastasis. However, the regulatory mechanisms of HIF2α protein stability remain poorly understood. The precise role of the deubiquitinase (DUB) ubiquitin‐specific peptidase 5… read more here.
Keywords: metastasis; hif2; proliferation; breast cancer ... See more keywords
Vertical sleeve gastrectomy increases duodenal Lactobacillus spp. richness associated with the activation of intestinal HIF2α signaling and metabolic benefits
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2022.101432
Abstract: Objective Vertical Sleeve Gastrectomy (VSG) is one of the most efficacious treatments for obesity and its comorbidities. Although a range of evidence suggests that alterations of the microbiota in the distal gut following VSG are… read more here.
Keywords: vsg; lactobacillus spp; duodenum; physiology ... See more keywords
Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.02.024
Abstract: BACKGROUND & AIMS Pancreatic ductal adenocarcinoma (PDAC) has a hypoxic, immunosuppressive stroma, which contributes to its resistance to immune checkpoint blockade therapies. The hypoxia-inducible factors (HIFs) mediate the cellular response to hypoxia, but their role… read more here.
Keywords: tumor; cancer; stromal hif2; microenvironment ... See more keywords
Abstract 2351: Cancer-associated fibroblasts modulate macrophage phenotype in PDAC through hypoxia inducible factor-2(HIF2)-dependent IGFBP3 secretion
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2351
Abstract: Introduction: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic stroma which induces profound intratumoral hypoxia within its tumor microenvironment (TME). PDAC has low levels of effector T cell infiltration and increased numbers of immunosuppressive… read more here.
Keywords: hif2; cafs; hypoxia; hif2 dependent ... See more keywords
Tailless and hypoxia inducible factor-2α cooperate to sustain proangiogenic states of retinal astrocytes in neonatal mice
Sign Up to like & getrecommendations! Published in 2023 at "Biology Open"
DOI: 10.1242/bio.059684
Abstract: ABSTRACT Tailless (TLX, an orphan nuclear receptor) and hypoxia inducible factor-2α (HIF2α) are both essential for retinal astrocyte and vascular development. Tlx−/− mutation and astrocyte specific Hif2α disruption in Hif2αf/f/GFAPCre mice are known to cause… read more here.
Keywords: hif2; tlx hif2; hypoxia inducible; retinal astrocytes ... See more keywords
Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0188438
Abstract: Multiple myeloma (MM) is an incurable disease of malignant plasma B-cells that infiltrate the bone marrow (BM), resulting in bone destruction, anemia, renal impairment and infections. Physiologically, the BM microenvironment is hypoxic and this promotes… read more here.
Keywords: myeloma; hif2; regulation hif2; mediated apoptosis ... See more keywords
Analysis of HIF2α polymorphisms in infertile women with polycystic ovary syndrome or unexplained infertility
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.986567
Abstract: Objective To evaluate HIF2α polymorphisms and glucose metabolism in a group of women with polycystic ovary syndrome (PCOS) or unexplained infertility (UI). Patients The infertile group (n=148) consisted of 96 women with PCOS, 52 women… read more here.
Keywords: infertile women; hif2; analysis hif2; women pcos ... See more keywords
FLCN Regulates HIF2α Nuclear Import and Proliferation of Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.00121
Abstract: Aims and Hypothesis: This study aims to explore the specific molecular mechanism of folliculin (FLCN)-induced proliferation, migration, and invasion in clear cell renal cell carcinoma (ccRCC) and to investigate the relationship of FLCN and HIF2α.… read more here.
Keywords: cell renal; flcn; proliferation; hif2 ... See more keywords
Protective Effects of Hif2 Inhibitor PT-2385 on a Neurological Disorder Induced by Deficiency of Irp2
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.715222
Abstract: Iron regulatory protein 2 (IRP2) deficiency in mice and humans causes microcytic anemia and neurodegeneration due to functional cellular iron depletion. Our previous in vitro data have demonstrated that Irp2 depletion upregulates hypoxia-inducible factor subunits… read more here.
Keywords: neurological disorder; glycolysis; irp2; hif2 ... See more keywords
Differential HIF2α Protein Expression in Human Carotid Body and Adrenal Medulla under Physiologic and Tumorigenic Conditions
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14122986
Abstract: Simple Summary Thoraco-abdominal paraganglioma and pheochromocytoma (PPGL) are pathogenically linked to mutations in SDH genes. Loss-of-function of SDH has been associated with stabilization of HIF2α, which otherwise would be degraded via oxygen-sensitive mechanisms. SDH dysfunction… read more here.
Keywords: carotid body; hif2; ppgl; hnpgl ... See more keywords
HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.54402
Abstract: Objective: Our previous study showed that glioma stem-like cells could be induced to undergo dedifferentiation under hypoxic conditions, but the mechanism requires further study. HIF1α and HIF2α are the main molecules involved in the response… read more here.
Keywords: hif2; hif1 hif2; sox2; dedifferentiation ... See more keywords