Abstract 2351: Cancer-associated fibroblasts modulate macrophage phenotype in PDAC through hypoxia inducible factor-2(HIF2)-dependent IGFBP3 secretion
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DOI: 10.1158/1538-7445.am2023-2351
Abstract: Introduction: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic stroma which induces profound intratumoral hypoxia within its tumor microenvironment (TME). PDAC has low levels of effector T cell infiltration and increased numbers of immunosuppressive… read more here.
Keywords: hif2; cafs; hypoxia; hif2 dependent ... See more keywords